Praxadine

Base Information

Chemical Name:Praxadine
CAS No.:4023-00-1
Molecular Formula:C4H6N4
Molecular Weight:110.118
Hs Code.:2933199090
UNII:12L58GX4AS
DSSTox Substance ID:DTXSID3048366
Nikkaji Number:J8.291K
Wikidata:Q27251420
NCI Thesaurus Code:C66457
Pharos Ligand ID:HVUNT2948QSQ
ChEMBL ID:CHEMBL503356
Mol file:4023-00-1.mol

Synonyms:pyrazole-1-carboxamidine

Suppliers and Price of Praxadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
Pyrazole-1-carboxamidine 96%
500g
$ 198.00

J&W Pharmlab
Pyrazole-1-carboxamidine 96%
100g
$ 52.00

Crysdot
1H-Pyrazole-1-carboximidamide 95+%
25g
$ 490.00

Chemenu
Pyrazole-1-carboxamidine 95%
25g
$ 458.00

American Custom Chemicals Corporation
1(H)-PYRAZOLE-1-CARBOXAMIDINE 95.00%
5G
$ 1590.46

American Custom Chemicals Corporation
1(H)-PYRAZOLE-1-CARBOXAMIDINE 95.00%
2.5G
$ 1255.54

American Custom Chemicals Corporation
1(H)-PYRAZOLE-1-CARBOXAMIDINE 95.00%
1G
$ 867.10

AccelPharmtech
1H-Pyrazole-1-carboximidamide 97.00%
5G
$ 2180.00

AccelPharmtech
1H-Pyrazole-1-carboximidamide 97.00%
1G
$ 1940.00

Total 12 raw suppliers

Chemical Property of Praxadine

Chemical Property:

Vapor Pressure:0.066mmHg at 25°C
Melting Point:97-101 °C
Refractive Index:1.683
Boiling Point:230.4°C at 760 mmHg
PKA:7.53±0.49(Predicted)
Flash Point:93.1°C
PSA：67.69000
Density:1.42g/cm³
LogP:1.22670
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:110.059246208
Heavy Atom Count:8
Complexity:100

Purity/Quality:

97% ^*data from raw suppliers

Pyrazole-1-carboxamidine 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(N=C1)C(=N)N

Technology Process of Praxadine

There total 2 articles about Praxadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 288-13-1
NH-pyrazole

: 420-04-2
CYANAMID

: 4023-00-1
1H-Pyrazole-1-carboxamidine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.6b01473

Reference yield:

: 4023-00-1
1H-Pyrazole-1-carboxamidine

Guidance literature:: Aminoguanidinbicarbonat, Propargylaldehyd, HCl (Ausb. 93percent);

Reference yield: 100.0%

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 4023-00-1
1H-Pyrazole-1-carboxamidine

: 959793-10-3
benzyl 4-carbamimidamidopiperidine-1-carboxylate

Guidance literature:: benzyl 4-aminopiperidine-1-carboxylate; 1H-Pyrazole-1-carboxamidine; With triethylamine; In acetonitrile; at 60 ℃; for 18h;

With sodium hydrogencarbonate; In water; Product distribution / selectivity;