ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate

Base Information

• Chemical Name: ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate
• CAS No.: 422570-02-3
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 422570-02-3.mol

Synonyms:ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate

Chemical Property of ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate

There total 3 articles about ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethanol (64-17-5) + 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoic acid (422570-00-1) → ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate (422570-02-3)

Guidance literature:

With sulfuric acid; for 24h; Heating;

DOI:10.1002/jhet.5570380630

Reference yield:

Diethyl phthalate (84-66-2) → ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate (422570-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / EtONa / 3 h / 130 °C

2: 56 percent / KOH / ethanol / 24 h / Heating

3: 92 percent / concd. H₂SO₄ / 24 h / Heating

With potassium hydroxide; sulfuric acid; sodium ethanolate; In ethanol; 2: retro-Claisen condensation;

DOI:10.1002/jhet.5570380630

Reference yield:

diethyl 5,9-dihydroxy-7H-benzo[a] cycloheptene-6,8-dicarboxylate (64044-74-2) → ethyl 2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoate (422570-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / KOH / ethanol / 24 h / Heating

2: 92 percent / concd. H₂SO₄ / 24 h / Heating

With potassium hydroxide; sulfuric acid; In ethanol; 1: retro-Claisen condensation;

DOI:10.1002/jhet.5570380630

upstream raw materials:

ethanol

2-[5-(3-ethoxy-3-oxopropyl)-6-oxo-2-phenyl-1,6-dihydro-4-pyrimidinyl]benzoic acid

Diethyl phthalate

diethyl 5,9-dihydroxy-7H-benzo[a] cycloheptene-6,8-dicarboxylate