(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Base Information

Chemical Name:(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene
CAS No.:178765-12-3
Molecular Formula:C₄₄H₈₄O₃Si₃
Molecular Weight:745.406
Hs Code.:

(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Synonyms:(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

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Chemical Property of (1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Chemical Property:

Purity/Quality:

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Hazard Codes:

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Technology Process of (1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

There total 9 articles about (1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-97-0
vitamin D₃

: 178765-12-3
(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 10 steps

1: O₃ / methanol / -78 °C

2: 89 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: tert-butyl nitrite / CHCl₃ / 0.67 h / Ambient temperature

4: 1.) C₆H₆, irrad., 10 deg C, 100 min, 2.) C₆H₆, RT, overnight

5: 86 percent / 1.5 h / Heating

6: 96 percent / 10percent KOH/MeOH / 1.5 h / 50 °C

7: 76 percent / K, HMPA, t-BuOH / diethyl ether / 5 h / Ambient temperature

8: 14 percent / RuCl₃, aq. NaIO₄ / CCl₄; acetonitrile / 72 h / Ambient temperature

9: 50 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

10: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 to 0 deg C, 17 h

With 1H-imidazole; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ruthenium trichloride; potassium hydroxide; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; tert.-butylnitrite; ozone; tert-butyl alcohol; In methanol; tetrachloromethane; diethyl ether; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950745t

Reference yield:

: 33813-99-9
Grundmann's alcohol

: 178765-12-3
(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 8 steps

1: tert-butyl nitrite / CHCl₃ / 0.67 h / Ambient temperature

2: 1.) C₆H₆, irrad., 10 deg C, 100 min, 2.) C₆H₆, RT, overnight

3: 86 percent / 1.5 h / Heating

4: 96 percent / 10percent KOH/MeOH / 1.5 h / 50 °C

5: 76 percent / K, HMPA, t-BuOH / diethyl ether / 5 h / Ambient temperature

6: 14 percent / RuCl₃, aq. NaIO₄ / CCl₄; acetonitrile / 72 h / Ambient temperature

7: 50 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

8: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 to 0 deg C, 17 h

With 1H-imidazole; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ruthenium trichloride; potassium hydroxide; sodium periodate; n-butyllithium; tert.-butylnitrite; tert-butyl alcohol; In tetrachloromethane; diethyl ether; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950745t

Reference yield:

: 66251-18-1
Grundmann's ketone

: 178765-12-3
(1R,3aR,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-octahydro-indene

Guidance literature:: Multi-step reaction with 9 steps

1: 89 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

2: tert-butyl nitrite / CHCl₃ / 0.67 h / Ambient temperature

3: 1.) C₆H₆, irrad., 10 deg C, 100 min, 2.) C₆H₆, RT, overnight

4: 86 percent / 1.5 h / Heating

5: 96 percent / 10percent KOH/MeOH / 1.5 h / 50 °C

6: 76 percent / K, HMPA, t-BuOH / diethyl ether / 5 h / Ambient temperature

7: 14 percent / RuCl₃, aq. NaIO₄ / CCl₄; acetonitrile / 72 h / Ambient temperature

8: 50 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

9: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 to 0 deg C, 17 h

With 1H-imidazole; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ruthenium trichloride; potassium hydroxide; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; tert.-butylnitrite; tert-butyl alcohol; In tetrachloromethane; diethyl ether; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950745t