5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

Base Information

Chemical Name:5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol
CAS No.:648433-60-7
Molecular Formula:C₂₉H₄₆O₆Si
Molecular Weight:518.766
Hs Code.:

Synonyms:5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

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Chemical Property of 5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

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Technology Process of 5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

There total 9 articles about 5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(2,3-dimethoxy-4-methyl-phenyl)-2-[methoxy-(4-methoxy-phenyl)-methoxy]-4-methyl-pentan-1-ol

: 648433-60-7
5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ja039124c

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 648433-60-7
5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.25 g / imidazole / dimethylformamide / 3 h

2: potassium carbonate / methanol / 3 h / 20 °C

3: 1.52 g / quinoline; H₂ / Pd/BaSO₄ / toluene / 12 h / 20 °C / 760 Torr

4: 38 percent / aq. OsO₄; 4-methylmorpholine N-oxide / 2-methyl-propan-2-ol; H₂O / 4 h / 20 °C

5: pyridinium p-toluenesulfonate / CH₂Cl₂ / 3 h / 20 °C

6: 78 mg / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

With 1H-imidazole; quinoline; osmium(VIII) oxide; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; Pd-BaSO₄; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/ja039124c

Reference yield:

: 648433-65-2
(2R,3S)-3-(2,3-Dimethoxy-4-methyl-phenyl)-2-methyl-5-trimethylsilanyl-pent-4-yn-1-ol

: 648433-60-7
5-(tert-butyldimethylsilanyloxy)-3-(2,3-dimethoxy-4-methylphenyl)-2-(4-methoxybenzyloxy)-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.25 g / imidazole / dimethylformamide / 3 h

2: potassium carbonate / methanol / 3 h / 20 °C

3: 1.52 g / quinoline; H₂ / Pd/BaSO₄ / toluene / 12 h / 20 °C / 760 Torr

4: 38 percent / aq. OsO₄; 4-methylmorpholine N-oxide / 2-methyl-propan-2-ol; H₂O / 4 h / 20 °C

5: pyridinium p-toluenesulfonate / CH₂Cl₂ / 3 h / 20 °C

6: 78 mg / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

With 1H-imidazole; quinoline; osmium(VIII) oxide; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; Pd-BaSO₄; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/ja039124c