trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1422428-00-9
Molecular Formula:C₃₉H₄₈N₆O₄
Molecular Weight:664.848
Hs Code.:

trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

Synonyms:trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

There total 5 articles about trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1180671-25-3
(S)-tert-butyl 2-(7-bromo-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

: trans-tert-butyl (2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)carbamate

: 1422428-00-9
trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.666667h; Microwave irradiation; Inert atmosphere;

Reference yield:

: trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

: 1422428-00-9
trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 - 40 °C

2: ammonium acetate / toluene / 15 h / 110 °C

3: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; water; toluene; acetonitrile;

Reference yield:

: trans-tert-butyl (2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)carbamate

: 1422428-00-9
trans-(2S)-tert-butyl 2-(7-(4-(2-(2-((tert-butoxycarbonyl)amino)cyclopentyl)-1H-imidazol-5-yl)phenyl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water;