methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
CAS No.:1422427-98-2
Molecular Formula:C₄₃H₅₄N₈O₆
Molecular Weight:778.952
Hs Code.:

methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Synonyms:methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

There total 7 articles about methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: (x)C₂HF₃O₂*C₂₉H₃₂N₆

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1422427-98-2
methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: N-methoxycarbonyl-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.333333h;

(x)C₂HF₃O₂*C₂₉H₃₂N₆; In acetonitrile; at 20 - 40 ℃;

Reference yield:

: trans-2-(4-bromophenyl)-2-oxoethyl-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylate

: 1422427-98-2
methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / toluene / 15 h / 110 °C

2.1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: dichloromethane / 2 h / 5 - 40 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h

5.2: 20 - 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

: 1422427-98-2
methyl trans-((2S)-1-((2-(5-(4-(2-((S)-1-((S)-2-(methoxycarbonyl)amino-3-methylbutanoyl)pyrrolidin-2-yl)-4,5-dihydro-1H-naphtho[1,2-d]imidazol-7-yl)phenyl)-1H-imidazol-2-yl)cyclopentyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 - 40 °C

2.1: ammonium acetate / toluene / 15 h / 110 °C

3.1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation; Inert atmosphere

5.1: dichloromethane / 2 h / 5 - 40 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h

6.2: 20 - 40 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;