6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Base Information

Chemical Name:6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one
CAS No.:656252-34-5
Molecular Formula:C₂₃H₄₀O₅Si
Molecular Weight:424.653
Hs Code.:

6-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Synonyms:6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Suppliers and Price of 6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

There total 9 articles about 6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 386703-38-4
tert-butyl-[2-methoxy-6-(2-methoxymethoxy-hex-5-enyl)-4-methyl-benzyloxy]-dimethyl-silane

: 656252-34-5
6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Guidance literature:: With palladium diacetate; copper diacetate; oxygen; In N,N-dimethyl acetamide; for 16h;
DOI:10.1021/ja030498f

Reference yield:

: N-tert-Butyl-2-methoxy-4-methylbenzamide

: 656252-34-5
6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: TMEDA; t-BuLi / tetrahydrofuran; pentane / 2 h / -20 °C

1.2: tetrahydrofuran; pentane / 2 h / -78 - 0 °C

2.1: 5.74 g / p-TsOH / toluene / 2 h / Heating

3.1: 91 percent / LAH / tetrahydrofuran / 0.5 h / 20 °C

4.1: 89 percent / Et₃N; DMF / CH₂Cl₂ / 14 h

5.1: 83 percent / i-Pr₂NEt / CH₂Cl₂ / 12 h

6.1: 81 percent / aq. Cu(OAc)2; Pd(OAc)2; O₂ / N,N-dimethyl-acetamide / 16 h

With palladium diacetate; lithium aluminium tetrahydride; copper diacetate; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; oxygen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; toluene; pentane; 6.1: Wacker oxidation;
DOI:10.1021/ja030498f

Reference yield:

: 386703-28-2
(S)-3-But-3-enyl-8-methoxy-6-methyl-isochroman-1-one

: 656252-34-5
6-[2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-5-methyl-phenyl]-5-methoxymethoxy-hexan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / LAH / tetrahydrofuran / 0.5 h / 20 °C

2: 89 percent / Et₃N; DMF / CH₂Cl₂ / 14 h

3: 83 percent / i-Pr₂NEt / CH₂Cl₂ / 12 h

4: 81 percent / aq. Cu(OAc)2; Pd(OAc)2; O₂ / N,N-dimethyl-acetamide / 16 h

With palladium diacetate; lithium aluminium tetrahydride; copper diacetate; oxygen; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; 4: Wacker oxidation;
DOI:10.1021/ja030498f