ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE
• CAS No.: 313967-69-0
• Molecular Formula: C₁₅H₁₆N₂O₅
• Molecular Weight: 304.302
• Mol file: 313967-69-0.mol

Synonyms:ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate

Chemical Property of ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE

Chemical Property:

• Melting Point: 134-136°C
• Boiling Point: 523.2±50.0 °C(Predicted)
• PKA: 13.54±0.70(Predicted)
• Density: 1.276±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE

There total 3 articles about ETHYL 2-METHYL-4-(4-NITROPHENYL)-6-OXO-1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl acetoacetate (141-97-9) + 4-nitrobenzaldehdye (555-16-8) → ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate (313967-69-0)

Guidance literature:

With BIURET; Bi(NO₃)3*ZnCl₂*Al₂O₃; at 140 ℃;

DOI:10.1002/jhet.5570450209

Reference yield: 66.0%

ethyl acetoacetate (141-97-9) + 4-nitrobenzaldehdye (555-16-8) + urea (57-13-6) → ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate (313967-69-0) + ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (123371-45-9,161374-08-9)

Guidance literature:

Bi(NO₃)3*ZnCl₂*Al₂O₃; at 140 ℃; for 14h;

DOI:10.1002/jhet.5570450209

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + ethyl acetoacetate (141-97-9) + 4-nitrobenzaldehdye (555-16-8) → ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyridine-5-carboxylate (313967-69-0)

Guidance literature:

With ammonium acetate; at 72 ℃; for 0.166667h; Microwave irradiation;

DOI:10.3998/ark.5550190.0012.909

upstream raw materials:

ethyl acetoacetate

4-nitrobenzaldehdye

urea

cycl-isopropylidene malonate

Downstream raw materials:

ethyl 2-methyl-4-(4-nitrophenyl)-6-thioxo-1,4,5,6-tetrahydropyridine-3-carboxylate

4-(4'-nitrophenyl)-3,4-dihydrofuro[3,4-b]pyridine-2,5-(1H,7H)-dione