1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide

Base Information

• Chemical Name: 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide
• CAS No.: 1322724-58-2
• Molecular Formula: C₁₅H₁₈ClN₅OS
• Molecular Weight: 351.86

Synonyms:1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide

Chemical Property of 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide

Chemical Property:

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Technology Process of 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide

There total 2 articles about 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Ethyl isothiocyanate (542-85-8) + 2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide (1322724-40-2) → 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide (1322724-58-2)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1007/s00044-011-9691-4

Reference yield:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester (63570-02-5) → 1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide (1322724-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / Reflux

2: ethanol / 6 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-011-9691-4

Reference yield: 70.0%

1-{2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl]acetyl}-4-ethylthiosemicarbazide (1322724-58-2) + 4-chlorobenzoylmethyl bromide (536-38-9) → N'-(4-(4-chlorophenyl)-3-ethylthiazol-2(3H)-ylidene)-2-(5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl)acetohydrazide

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux;

DOI:10.1016/j.bioorg.2021.104883

upstream raw materials:

[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-acetic acid ethyl ester

Ethyl isothiocyanate

2-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-yl] acetic acid hydrazide

Downstream raw materials:

5-[5-(4-chlorophenyl)-3-methyl-1H-pyrazol-1-ylmethyl]-4-ethyl-2H-1,2,4-triazole-3-thione

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