O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine

Base Information

• Chemical Name: O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine
• CAS No.: 142764-01-0
• Molecular Formula: C₂₂H₂₃NO₅S
• Molecular Weight: 413.494
• Mol file: 142764-01-0.mol

Synonyms:O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine

Chemical Property of O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine

There total 2 articles about O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(benzo[b]thiophen-2-yl)ethanol (51868-95-2) + N-(phenoxycarbonyl)-O-(tert-butyloxycarbonyl)hydroxylamine (141580-70-3) → C22H23NO5S (142764-02-1,142764-03-2) + O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine (142764-01-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jo00044a046

Reference yield:

phenyl N-hydroxycarbamate (38064-07-2) → O-(tert-butyloxycarbonyl)-N-(phenoxycarbonyl)-N-(1-benzothien-2-ylethyl)hydroxylamine (142764-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 1 N NaOH / tetrahydrofuran / 2 h / Ambient temperature

2: 50 percent / PPh₃, diisopropyl azodicarboxylate / tetrahydrofuran / 0 °C

With sodium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

DOI:10.1021/jo00044a046

upstream raw materials:

1-(benzo[b]thiophen-2-yl)ethanol

N-(phenoxycarbonyl)-O-(tert-butyloxycarbonyl)hydroxylamine

phenyl N-hydroxycarbamate