51868-95-2

Basic information

• Product Name: 1-BENZO[B]THIOPHEN-2-YL-ETHANOL
• Synonyms: 1-BENZO[B]THIOPHEN-2-YL-ETHANOL;BENZO[B]THIOPHENE-2-ETHANOL;1-Benzothiophen-2-ylethanol;1-BENZO[B]THIOPHEN-2;1-(1-benzothiophen-2-yl)ethan-1-ol;2-(hydroxyethyl)benzothiophene;1-Benzo[B]Thiophen-2-Yl-Ethanol(WX642067)
• CAS NO: 51868-95-2
• Molecular Formula: C₁₀H₁₀OS
• Molecular Weight: 178.2508
• Mol File: 51868-95-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 58-58.3 °C
• Boiling Point: 317.8 °C at 760 mmHg
• Flash Point: 146 °C
• Appearance: /
• Density: 1.236 g/cm³
• Vapor Pressure: 0.000157mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 13.95±0.20(Predicted)
• CAS DataBase Reference: 1-BENZO[B]THIOPHEN-2-YL-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZO[B]THIOPHEN-2-YL-ETHANOL(51868-95-2)
• EPA Substance Registry System: 1-BENZO[B]THIOPHEN-2-YL-ETHANOL(51868-95-2)

Safety Data

• Hazardous Substances Data: 51868-95-2(Hazardous Substances Data)

Usage

General Description

1-Benzo[b]thiophen-2-yl-ethanol is a chemical compound that belongs to the class of organic compounds known as benzothiophenes, which are aromatic compounds containing a benzene fused to a thiophene ring. It has an alcohol functional group (an ethanolic side chain) attached to its benzothiophene core. The detailed physical properties of this chemical, such as its melting point, boiling point and solubility in various solvents may vary and are usually explored in the context of specific scientific experiments or manufacturing processes. Its potential applications or hazards vary widely and can also only be accurately determined in a specific context. It is often used in research and experimental settings in various branches of chemistry.

InChI:InChI=1/C10H10OS/c1-7(11)10-6-8-4-2-3-5-9(8)12-10/h2-7,11H,1H3

Upstream product

• 50779-55-0 benzothiophen-2-yllithium 
• 75-07-0 acetaldehyde 
• 22720-75-8 2-acetyl benzo[b]thiophene 
• 95-15-8 Benzo[b]thiophene 
• 29199-11-9 2-formylthiophenol 
• 75-36-5 acetyl chloride 

Downstream Products

• 212705-00-5 4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenol 
• 212704-99-9 4-[1-(benzo[b]thien-2-yl)ethyl]phenol 
• 22720-75-8 2-acetyl benzo[b]thiophene 
• 1606160-74-0 (rac)-1-(benzo[b]thiophen-2-yl)-3-phenylpropan-1-ol 
• 1026256-93-8 phenyl 1-(benzo[b]thiophen-2-yl)ethyl(hydroxyl)carbamate 
• 1206596-73-7 1-(1-benzo[b]thien-2-yl-ethyl)-N-phenyl-2,2,2-trifluoroacetimidate 
• 142606-21-1 zileuton 
• 212705-03-8 [4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)phenyl] trifluoromethanesulfonate 
• 212705-04-9 methyl 4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)benzoate 
• 212705-06-1 4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)benzenemethanol 
• 212705-07-2 4-[1-(benzo[b]thien-2-yl)ethyl]-2-(methylthio)benzaldehyde 
• 281191-13-7 5-[1-(benzo[b]thien-2-yl)ethyl]-2-(S-dimethylthiocarbamate)benzaldehyde 
• 281191-12-6 5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde 
• 281191-11-5 5-[1-(benzo[b]thien-2-yl)ethyl]-2-hydroxybenzaldehyde 

Relevant articles and documents

Diastereoselective photochromism of a bisbenzothienylethene governed by steric as well as electronic interactions

Introduction of an asymmetric center to C-2 of one of the benzothiophene rings of bisbenzothienylperfluorocyclopentene results in a highly diastereoselective photochromic system. The stereogenic center bears a hydrogen atom, a methyl group, and a methoxymethoxy group. The steric as well as the electronic repulsions gave an 87-88% diastereomer excess in various solvents at room temperature with 80-85% conversion to the colored form. The enantioselective synthesis was also carried out. Upon photoirradiation in hexane, a change in optical rotation at 820 nm, where neither the open form nor the colored form absorbs light, was observed repeatedly. Copyright

FLP-Catalyzed Transfer Hydrogenation of Silyl Enol Ethers

Herein we report the first catalytic transfer hydrogenation of silyl enol ethers. This metal free approach employs tris(pentafluorophenyl)borane and 2,2,6,6-tetramethylpiperidine (TMP) as a commercially available FLP catalyst system and naturally occurring γ-terpinene as a dihydrogen surrogate. A variety of silyl enol ethers undergo efficient hydrogenation, with the reduced products isolated in excellent yields (29 examples, 82 % average yield).

Tailored sol-gel immobilized lipase preparates for the enzymatic kinetic resolution of heteroaromatic alcohols in batch and continuous flow systems

Tailored immobilized lipases from Candida antarctica B and Pseudomonas fluorescens, with improved thermal and operational stability, were prepared through fine tuning of the structure of the sol-gel matrix, using various binary or ternary precursor mixtures for the EKR of various chiral heteroaromatic secondary alcohols with benzofuran, benzo[b]thiophen, phenothiazine and 2-phenylthiazol moieties. The operational stability in batch process was studied for five selected systems by performing reuse experiments, using the conversion, enantiomeric excesses and enantiomeric ratio as parameters, demonstrating the dependence of the sol-gel lipase preparate performance on the structure of both biocatalyst and substrate. The resolution of the benzofuranic substrates with the best performing biocatalysts was studied in continuous-flow mode, using the productivity as a criterion. The specific reaction rates under continuous-flow operation (rflow) were higher than those obtained in batch mode (rbatch) in both cases, sustaining its usefulness for further process development.