N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

Base Information

Chemical Name:N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine
CAS No.:1606178-31-7
Molecular Formula:C₂₁H₃₂N₄S
Molecular Weight:372.578
Hs Code.:

N<sup>4</sup>-butyl-N<sup>4</sup>-ethyl-N<sup>6</sup>-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

Synonyms:N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

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Technology Process of N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

There total 5 articles about N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 13360-63-9
N-ethylbutylamine

: 1606178-62-4
6-chloro-N-mesityl-2-methyl-5-(methylthio)pyrimidin-4-amine

: 1606178-31-7
N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

: 6095-82-5
2,4,6-trimethylphenyl isothiocyanate

: 1606178-31-7
N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sulfur / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: Reflux; Inert atmosphere

3.1: sodium hydroxide / 100 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: trichlorophosphate / Inert atmosphere; Reflux

5.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; sulfur; triethylamine; sodium hydroxide; XPhos; trichlorophosphate; In dimethyl sulfoxide; 1.1: |Gewald Aminoheterocycles Synthesis / 1.2: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

: 246166-36-9
4-amino-3-mesityl-2-thioxo-2,3-dihydrothiazole-5-carboxamide

: 1606178-31-7
N⁴-butyl-N⁴-ethyl-N⁶-mesityl-2-methyl-5-(methylthio)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Reflux; Inert atmosphere

2.1: sodium hydroxide / 100 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / Inert atmosphere; Reflux

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; sodium hydroxide; XPhos; trichlorophosphate;
DOI:10.1016/j.ejmech.2014.03.040