(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

Base Information

Chemical Name:(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol
CAS No.:343949-98-4
Molecular Formula:C₁₅H₂₂O₃
Molecular Weight:250.338
Hs Code.:

Synonyms:(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

Suppliers and Price of (2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

Chemical Property:

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Technology Process of (2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

There total 1 articles about (2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 343950-02-7
((2S,3R,5R)-5-Benzyloxymethyl-3-methyl-tetrahydro-furan-2-yl)-acetic acid ethyl ester

: 343949-98-4
(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

Guidance literature:: ((2S,3R,5R)-5-Benzyloxymethyl-3-methyl-tetrahydro-furan-2-yl)-acetic acid ethyl ester; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 1.5h;

With Rochelle's salt; In methanol; hexane; dichloromethane; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/ol015741z

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 343949-98-4
(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

: 537007-20-8
(2S,3R,5R)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-5-benzyloxymethyl-3-methyltetrahydrofuran

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(03)00142-X

Reference yield:

: 343949-98-4
(2'S,3'R,5'R)-2-(5'benzyloxymethyl-3'-methyl-tetrahydrofuran-2'-yl)-ethanol

: bis-(R)-MTPA ester of C-1-C-7 segment of amphidinolide C

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 4 h / 20 °C

2: DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/ol015741z