4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

Base Information

Chemical Name:4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide
CAS No.:1448859-90-2
Molecular Formula:C₂₆H₂₈N₂O₂
Molecular Weight:400.521
Hs Code.:

Synonyms:4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

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Chemical Property of 4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

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Technology Process of 4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

There total 4 articles about 4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1448859-81-1
4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 1448859-90-2
4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

Guidance literature:: 4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

cyclohexylamine; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm400947b

Reference yield:

: 4-benzoyl-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 1448859-90-2
4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetra(n-butyl)ammonium hydroxide / dichloromethane; water / 0 - 20 °C

2.1: sodium hydroxide / methanol / Reflux

2.2: pH Ca_. 3

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 20 °C

With tetra(n-butyl)ammonium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400947b

Reference yield:

: 1448859-76-4
4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 1448859-90-2
4-benzoyl-1-benzyl-5-methyl-1H-pyrrole-2-carboxylic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / Reflux

1.2: pH Ca_. 3

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm400947b