(2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

Base Information

Chemical Name:(2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester
CAS No.:69877-15-2
Molecular Formula:C₁₆H₁₆F₃N₃O₄
Molecular Weight:371.316
Hs Code.:

Synonyms:(2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

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Chemical Property of (2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

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Technology Process of (2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

There total 3 articles about (2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4755-77-5
Ethyl oxalyl chloride

: 69877-23-2
2-amino-6-morpholin-4-yl-4-trifluoromethyl-benzonitrile

: 69877-15-2
(2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

Guidance literature:: With pyridine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00138a020

Reference yield:

: 69877-24-3
2-morpholin-4-yl-6-nitro-4-trifluoromethyl-benzonitrile

: 69877-15-2
(2-cyano-3-morpholin-4-yl-5-trifluoromethyl-phenyl)-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Fe, conc. HCl / methanol / 0.25 h / Heating

2: 79 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; hydrogenchloride; iron; In methanol; dichloromethane;
DOI:10.1021/jm00138a020