(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:212691-56-0
Molecular Formula:C₄₀H₄₆N₂O₁₀SSi
Molecular Weight:774.964
Hs Code.:

(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Synonyms:(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Chemical Property of (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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Technology Process of (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 17 articles about (4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 212691-56-0
(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / imidazole / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

2: ZnBr₂ / Rh₂(C₇H₁₅CO₂)4 / CH₂Cl₂ / 1.5 h / Heating

3: Et₃N, i-Pr₂NEt / CH₂Cl₂ / 1 h / -40 °C

5: 93 percent / aq. potassium phthalate / tetrahydrofuran / 16 h / Ambient temperature; pH 4.0

6: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With 1H-imidazole; potassium phthalate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; Rh₂(C₇H₁₅CO₂)4; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo980381n

Reference yield:

: 90822-24-5
(γR,2R,3S)-α-diazo-3-[(1R)-1-hydroxyethyl]-γ-methyl-β,4-dioxo-2-azetidinebutanoic acid (4-nitrophenyl)methyl ester

: 212691-56-0
(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / imidazole / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

2: ZnBr₂ / Rh₂(C₇H₁₅CO₂)4 / CH₂Cl₂ / 1.5 h / Heating

3: Et₃N, i-Pr₂NEt / CH₂Cl₂ / 1 h / -40 °C

5: 93 percent / aq. potassium phthalate / tetrahydrofuran / 16 h / Ambient temperature; pH 4.0

6: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With 1H-imidazole; potassium phthalate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; Rh₂(C₇H₁₅CO₂)4; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo980381n

Reference yield:

: 186817-88-9
(R)-2-Diazo-3-oxo-4-[(2R,3S)-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-2-yl]-pentanoic acid 4-nitro-benzyl ester

: 212691-56-0
(4S,5R,6S)-4-Methyl-7-oxo-3-[9-oxo-7-(propane-1-sulfonyloxymethyl)-9H-fluoren-3-yl]-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ZnBr₂ / Rh₂(C₇H₁₅CO₂)4 / CH₂Cl₂ / 1.5 h / Heating

2: Et₃N, i-Pr₂NEt / CH₂Cl₂ / 1 h / -40 °C

4: 93 percent / aq. potassium phthalate / tetrahydrofuran / 16 h / Ambient temperature; pH 4.0

5: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With potassium phthalate; triethylamine; N-ethyl-N,N-diisopropylamine; zinc dibromide; Rh₂(C₇H₁₅CO₂)4; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo980381n