(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Base Information

Chemical Name:(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol
CAS No.:113432-68-1
Molecular Formula:C₂₅H₃₆O₄
Molecular Weight:400.558
Hs Code.:

Synonyms:(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Suppliers and Price of (1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

There total 13 articles about (1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 100-39-0
benzyl bromide

: 113432-58-9
(R)-4-((1R,2S,3aS,5S,8R)-7a-Hydroxy-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-2-yl)-pentanoic acid methyl ester

: 113432-68-1
(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Guidance literature:: With potassium hydride;
DOI:10.1016/S0040-4039(00)96035-0

Reference yield:

: 111596-77-1,113474-01-4
(E)-4-[(1S,3S,4R,5R)-5-Hydroxy-1-methoxymethoxy-3-((E)-propenyl)-bicyclo[2.2.2]oct-2-yl]-but-2-enoic acid methyl ester

: 113432-68-1
(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 94 percent / PCC

2: 97 percent / t-BuOK / tetrahydrofuran / -78 °C / var. temp.

3: HCl / ethanol / 25 °C

4: dl-CSA / benzene / 50 °C

5: NaBH₄

6: 93 percent / iPr₂EtN / 1,2-dichloro-ethane / 60 °C

7: 1.) LDA / 1.) THF, -78 deg C, 2.) -78 to 25 deg C

8: 1.) O₃, 2.) Me₂S

9: 1.) DIBAH / 1.) THF, -78 deg C, 2.) ClCH₂CH₂Cl, 40 deg C

10: 84 percent / H₂ / 10percent Pd/C

11: 96 percent / n-Bu₃P / pyridine / 100 °C

12: 1.) MCPBA, 2.) i-Pr₂EtN / 2.) 1,2-dichlorobenzene, 180 deg C

13: 78 percent / KH

With hydrogenchloride; sodium tetrahydroborate; dimethylsulfide; tributylphosphine; DL-10-camphorsulfonic acid; potassium tert-butylate; hydrogen; potassium hydride; diisobutylaluminium hydride; ozone; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; 1,2-dichloro-ethane; benzene;
DOI:10.1016/S0040-4039(00)96035-0

Reference yield:

: 111596-61-3
(E)-4-[(1S,3R,4R)-1-Methoxymethoxy-5-oxo-3-((E)-propenyl)-bicyclo[2.2.2]oct-2-yl]-but-2-enoic acid methyl ester

: 113432-68-1
(1R,2S,3aS,5S,8R)-2-((R)-4-Benzyloxy-1-methyl-butyl)-8-methoxymethoxy-4-methylene-octahydro-1,5-methano-inden-7a-ol

Guidance literature:: Multi-step reaction with 12 steps

1: 97 percent / t-BuOK / tetrahydrofuran / -78 °C / var. temp.

2: HCl / ethanol / 25 °C

3: dl-CSA / benzene / 50 °C

4: NaBH₄

5: 93 percent / iPr₂EtN / 1,2-dichloro-ethane / 60 °C

6: 1.) LDA / 1.) THF, -78 deg C, 2.) -78 to 25 deg C

7: 1.) O₃, 2.) Me₂S

8: 1.) DIBAH / 1.) THF, -78 deg C, 2.) ClCH₂CH₂Cl, 40 deg C

9: 84 percent / H₂ / 10percent Pd/C

10: 96 percent / n-Bu₃P / pyridine / 100 °C

11: 1.) MCPBA, 2.) i-Pr₂EtN / 2.) 1,2-dichlorobenzene, 180 deg C

12: 78 percent / KH

With hydrogenchloride; sodium tetrahydroborate; dimethylsulfide; tributylphosphine; DL-10-camphorsulfonic acid; potassium tert-butylate; hydrogen; potassium hydride; diisobutylaluminium hydride; ozone; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; 1,2-dichloro-ethane; benzene;
DOI:10.1016/S0040-4039(00)96035-0