Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

Base Information

Chemical Name:Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride
CAS No.:116700-44-8
Molecular Formula:C₂₄H₂₃N₅O₂S*ClH
Molecular Weight:482.006
Hs Code.:

Synonyms:Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

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Chemical Property of Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

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Technology Process of Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

There total 2 articles about Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 116700-36-8
H-9

: 5416-30-8
N,N'-diphenyl-S-methyl isothiourea

: 116700-44-8
Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

Guidance literature:: With sodium hydroxide; In water; at 80 ℃; for 3h;
DOI:10.1021/jm00121a009

Reference yield:

: 84468-15-5
5-isoquinolinesulfonyl chloride

: 116700-44-8
Isoquinoline-5-sulfonic acid [2-(N',N''-diphenyl-guanidino)-ethyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: 24 percent / 2 N NaOH / H₂O / 3 h / 80 °C

With sodium hydroxide; In dichloromethane; water;
DOI:10.1021/jm00121a009