2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Base Information

• Chemical Name: 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
• CAS No.: 1278593-91-1
• Molecular Formula: C₄₅H₄₀N₁₀O₈
• Molecular Weight: 848.875

Synonyms:2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property of 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

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Technology Process of 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

There total 1 articles about 2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-benzoyl-N9-propargyladenine (1278593-88-6) + 2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine (177980-10-8) → 2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-91-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; pyridine; water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c0ob00438c

Reference yield: 62.0%

2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-91-1) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-92-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c0ob00438c

Reference yield:

2'-(4-(N6-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine (1278593-91-1) + benzoyl chloride (98-88-4) → N6-benzoyl-N9-propargyladenine (1278593-88-6)

Guidance literature:

With pyridine; at 20 - 120 ℃; for 23h; Inert atmosphere;

DOI:10.1039/c0ob00438c

upstream raw materials:

N₆-benzoyl-N₉-propargyladenine

2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Downstream raw materials:

2'-(4-(N₆-benzoyladenine-9-ylmethyl)-1,2,3-triazole-1-yl)-3'-O-(P-2-cyanoethyl-N,N-diisopropylaminophosphinyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

N₆-benzoyl-N₉-propargyladenine

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