(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

Base Information

Chemical Name:(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide
CAS No.:329914-19-4
Molecular Formula:C₂₆H₄₃NO₄Si
Molecular Weight:461.717
Hs Code.:

Synonyms:(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

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Chemical Property of (5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

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Technology Process of (5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

There total 1 articles about (5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 123707-26-6
N,N'-dimethoxy-N,N'-dimethyl urea

: C₂₃H₃₇LiO₂Si

: 329914-19-4
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

Guidance literature:: In tetrahydrofuran; at -78 - 0 ℃; for 1h;
DOI:10.1021/jo0056951

Reference yield: 96.0%

: 329914-19-4
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

: 329914-20-7
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonanecarboxamide

Guidance literature:: With hydrogen; Lindlar's catalyst; In ethyl acetate; for 22h;
DOI:10.1021/jo0056951

Reference yield:

: 329914-19-4
(5R,6S,7S)-N-methyl,N-methoxy-9-benzyloxy-4,5-dimethyl-5-(triethylsilyl)oxy-2-nonynecarboxamide

: 329914-23-0
(S)-4-[(2S,3R,6R,8S,9S)-8-((R)-4-Benzyloxy-1-methyl-butyl)-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / Pd/CaCO₃/Pb / ethyl acetate / 22 h

2: 88 percent / tetrahydrofuran / 1 h / -78 - 0 °C

3: 95 percent / H₂ / Pd/CaCO₃/Pb / ethyl acetate / 26 h

4: 50 percent / aq. HCl / methanol / 3 h

5: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 1 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; Lindlar's catalyst; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 5: Dess-Martin oxidation;
DOI:10.1021/jo0056951