3-Methyl-2-o-tolyl-3H-quinazolin-4-one

Base Information

• Chemical Name: 3-Methyl-2-o-tolyl-3H-quinazolin-4-one
• CAS No.: 24303-76-2
• Molecular Formula: C16H14 N2 O
• Molecular Weight: 250.3
• NSC Number: 97422
• DSSTox Substance ID: DTXSID10294615
• Nikkaji Number: J3.108.563B
• Wikidata: Q82033995
• ChEMBL ID: CHEMBL1488415
• Mol file: 24303-76-2.mol

Synonyms:24303-76-2;3-Methyl-2-o-tolyl-3H-quinazolin-4-one;3-Methyl-2-(o-tolyl)quinazolin-4(3H)-one;NSC97422;Cambridge id 6076099;MLS001207456;CHEMBL1488415;DTXSID10294615;HMS1671G08;HMS2846K08;NSC-97422;AKOS000514112;SMR000516872;Quinazolinone, 3-methyl-2-(O-tolyl)-4-(3H)-;SR-01000440065;SR-01000440065-1;3-methyl-2-(2-methylphenyl)-3,4-dihydroquinazolin-4-one

Chemical Property of 3-Methyl-2-o-tolyl-3H-quinazolin-4-one

Chemical Property:

• Vapor Pressure: 5.34E-07mmHg at 25°C
• Boiling Point: 412°Cat760mmHg
• Flash Point: 203°C
• Density: 1.16g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2=NC3=CC=CC=C3C(=O)N2C

Technology Process of 3-Methyl-2-o-tolyl-3H-quinazolin-4-one

There total 8 articles about 3-Methyl-2-o-tolyl-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

o-xylene (95-47-6) + 2-Amino-N-methylbenzamid (4141-08-6) → 3-methyl-2-(2-methylphenyl)-4(3H)-quinazolinone (24303-76-2)

Guidance literature:

With di-tert-butyl peroxide; iron(III) chloride hexahydrate; In dimethyl sulfoxide; at 110 ℃; for 40h; Sealed tube;

DOI:10.1039/d0ob00866d

Reference yield: 82.0%

2-oxo-2-o-tolylacetic acid + 2-Amino-N-methylbenzamid (4141-08-6) → 3-methyl-2-(2-methylphenyl)-4(3H)-quinazolinone (24303-76-2)

Guidance literature:

With air; In water; at 110 ℃; for 12h; Green chemistry;

DOI:10.1021/acs.joc.1c01497

Reference yield: 80.0%

2-methylphenyl aldehyde (529-20-4) + 2-Amino-N-methylbenzamid (4141-08-6) → 3-methyl-2-(2-methylphenyl)-4(3H)-quinazolinone (24303-76-2)

Guidance literature:

With sulfonic acid-based ionic liquid catalyst; at 120 ℃; for 6h;

upstream raw materials:

2-methylphenyl aldehyde

2-Amino-N-methylbenzamid

o-xylene

2-Methylbenzonitrile

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