4141-08-6

Usage

Uses

Used in Agriculture:
2-AMINO-N-METHYLBENZAMIDE is used as a plant safening agent for enhancing the tolerance of crops to various fertilizers, fungicides, insecticides, and herbicides. It helps in reducing the potential negative effects of these chemicals on plant growth and development, ensuring a higher yield and better quality of the produce.
Used in Fertilizers:
2-AMINO-N-METHYLBENZAMIDE is used as a safening agent in the fertilizer industry to improve the efficiency of nutrient uptake by plants. It helps in reducing the potential phytotoxic effects of certain fertilizer components, allowing for better nutrient utilization and overall plant health.
Used in Fungicides:
In the fungicide industry, 2-AMINO-N-METHYLBENZAMIDE is used as a safening agent to minimize the potential negative impact of fungicides on plant growth. It helps in maintaining the balance between effective disease control and plant health, ensuring a robust and healthy crop.
Used in Insecticides:
2-AMINO-N-METHYLBENZAMIDE is used as a safening agent in the insecticide industry to reduce the potential negative effects of insecticides on non-target plants. It helps in protecting beneficial plants while effectively controlling pests, leading to a more sustainable and environmentally friendly approach to pest management.
Used in Herbicides:
In the herbicide industry, 2-AMINO-N-METHYLBENZAMIDE is used as a safening agent to protect desirable plants from the harmful effects of herbicides. It helps in ensuring selective weed control, allowing farmers to maintain a healthy and productive crop while effectively managing weed populations.

InChI:InChI=1/C8H10N2O/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,9H2,1H3,(H,10,11)

Upstream product

• 118-48-9 isatoic anhydride 
• 74-89-5 methylamine 
• 16285-32-8 2,3-dihydro-3-methyl-2-phenylquinazolin-4(1H)-one 
• 552-16-9 ortho-nitrobenzoic acid 
• 606-27-9 methyl 2-nitrobenzoate 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 91-56-5 indole-2,3-dione 
• 123-39-7 N-Methylformamide 
• 100-52-7 benzaldehyde 
• 610-14-0 2-nitrobenzyl chloride 
• 28144-70-9 anthranilic acid amide 
• 118-92-3 anthranilic acid 
• 593-51-1 methylamine hydrochloride 
• 4454-32-4 1-benzyl-2-methyl-1,2-dihydro-indazol-3-one 

Downstream Products

• 59525-16-5 2-acetamido-N-methylbenzamide 
• 127082-54-6 2-Benzamido-N-methylbenzamide 
• 607-19-2 3-methyl-2,4(1H,3H)-quinazolinedione 
• 2436-66-0 3-methylquinazolin-4(3H)-one 
• 16353-13-2 N-formyl-anthranilic acid methylamide 
• 57946-97-1 N-methyl-2-(trifluoromethanesulfonamido)benzamide 
• 28257-01-4 2,3-dihydro-3-methyl-2-phenylbenzo[d][1,3,2]diazaborinin-4(1H)-one 
• 76164-69-7 Ethyl 3-(2-N-Methylcarbamoylanilino)methylene-2,4-dioxovalerate 
• 2415-10-3 2-amino-N-methylthiobenzamide 
• 306996-58-7 2-(3-chloropropionylamino)-N-methylbenzamide 
• 376351-04-1 2-(3-hydroxy-propylamino)-N-methyl-benzamide 
• 376351-03-0 2-(2-hydroxy-ethylamino)-N-methyl-benzamide 
• 1904-71-8 2-(methylaminomethyl)aniline dihydrochloride 
• 1769-25-1 2,3-dimethyl-4(3H)-quinazolinone 

Relevant academic research and scientific papers

Discovery and antitumor activity of Benzo[d]imidazol-containing 2,4-diarylaminopyrimidine analogues as ALK inhibitors with mutation-combating effects

To address drug resistance caused by ALK kinase mutations, a series of novel 2,4-diarylaminopyrimidine (DAAP) analogues were designed by incorporating 1H-benzo[d]imidazol motif onto the maternal framework. All compounds were efficiently synthesized and an

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

Design, synthesis, biological activities and 3D-QSAR studies of quinazolinone derivatives containing hydrazone structural units

In this study, three series of quinazolinone derivatives containing hydrazone structures were designed and synthesized. Bioactivity assays indicated that these compounds showed good antitumour activities towards human lung cancer cells (A549) and human pr

Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.

Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2,3-dihydroquinazolin-4(1H)-one

Herein, an electrocatalytic protocol for the synthesis of 2,3-dihydroquinazolin-4(1H)-one has been disclosed. Methanol is activated and utilized as the C1 source to cyclize with 2-aminobenzamides. This cyclization reaction proceeds conveniently (room temperature and air atmosphere) without any homogeneous metal catalysts, external oxidants, or bases. A wide variety of N,N-disubstituted 2,3-dihydroquinazolin-4(1H)-ones are obtained via this approach. Moreover, when methanol-d4 is used, a deuterated methylene motif is incorporated into the N-heterocycles, providing an efficient approach to the deuterated N-heterocycles.

Direct synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes

A novel catalytic system is reported for the construction of quinazolinones via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides with amides and aldehydes. Subsequent selective hydrosilylation of the quinazolinones using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines with structural diversity. The developed methodology proceeds with a broad substrate scope, excellent functional group tolerance, and utilizes a reusable catalyst and air as a green oxidant.

Green synthesis of novel phosphonate derivatives using ultrasonic irradiation

[Figure not available: see fulltext.] A novel and efficient procedure for the generation of quinazolinone phosphonate derivatives employing the reaction of euparin, isatin or its derivatives, primary amines, dialkyl acetylenedicarboxylates, trimethyl phosphite or triphenyl phosphite, and acidic solution of hydrogen peroxide in aqueous media at ambient temperature under ultrasonic irradiation was developed. Without ultrasonic irradiation, the reaction does not proceed and agitation of the reaction mixture is difficult. Some advantages of this procedure are: short time of reaction, high yields of products, easy isolation of products.

Quinazolinone compound containing hydrazone structural unit or stereoisomer, salt or solvate of the quinazolinone compound

The invention relates to a quinazolinone compound containing a hydrazone structural unit, or a stereoisomer, or a salt or a solvate of the quinazolinone compound. The compound has a structure as shownin a general formula (I) shown in the specification. Th

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell li

Pyrroformyl-containing 2,4-diaminopyrimidine derivatives as a new optimization strategy of ALK inhibitors combating mutations

Aiming to identify new optimization strategy effective for ALK-mutations, two series of pyrroformyl-containing 2,4-diaminopyrimidine compounds (11a-o, 12a-o) were designed, synthesized and evaluated for their anti-proliferative activities against three ca