4141-08-6

Basic information

• Product Name: 2-AMINO-N-METHYLBENZAMIDE
• Synonyms: BUTTPARK 34\02-07;2-AMINO-N-METHYLBENZAMIDE;Benzamide, 2-amino-N-methyl- (9CI);2-Amino-N-methylbenzamide 98%;Benzamide, 2-amino-N-methyl-;2-(Methylcarbamoyl)aniline;[2-[(MethylaMino)carbonyl]phenyl]aMine;Anthranilic Acid MethylaMide
• CAS NO: 4141-08-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: AMINEPRIMARY;AMIDE;Drug Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 4141-08-6.mol
• Article Data: 56

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 346.7 °C at 760 mmHg
• Flash Point: 163.5 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 5.66E-05mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol
• PKA: 14.73±0.46(Predicted)
• CAS DataBase Reference: 2-AMINO-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-METHYLBENZAMIDE(4141-08-6)
• EPA Substance Registry System: 2-AMINO-N-METHYLBENZAMIDE(4141-08-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4141-08-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-Amino-N-methylbenzamide is a plant safening agent selected from auxins, auxin precursors, metabolites or derivatives, and acetaminophen or a derivative. Safening examples are provided for fertilizer s, fungicides, insecticides, and herbicides.

InChI:InChI=1/C8H10N2O/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,9H2,1H3,(H,10,11)

Upstream product

• 88070-48-8 N-methylbenzamide 
• 118-48-9 isatoic anhydride 
• 118-92-3 anthranilic acid 
• 74-89-5 methylamine 
• 91-56-5 indole-2,3-dione 
• 123-39-7 N-Methylformamide 
• 100-52-7 benzaldehyde 
• 610-14-0 2-nitrobenzyl chloride 
• 5344-90-1 2-Aminobenzyl alcohol 
• 28144-70-9 anthranilic acid amide 
• 593-51-1 methylamine hydrochloride 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 606-27-9 methyl 2-nitrobenzoate 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 59525-16-5 2-acetamido-N-methylbenzamide 
• 127082-54-6 2-Benzamido-N-methylbenzamide 
• 76164-69-7 Ethyl 3-(2-N-Methylcarbamoylanilino)methylene-2,4-dioxovalerate 
• 142141-40-0 2-((ethylamino)methyl)aniline 
• 1904-69-4 2-amino-N-methylbenzylamine 
• 2415-10-3 2-amino-N-methylthiobenzamide 
• 53824-91-2 2-ω-chloroacetylamino-N-methylbenzamide 
• 74375-17-0 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one 
• 306996-58-7 2-(3-chloropropionylamino)-N-methylbenzamide 
• 376351-04-1 2-(3-hydroxy-propylamino)-N-methyl-benzamide 
• 1904-71-8 2-(methylaminomethyl)aniline dihydrochloride 
• 1769-25-1 2,3-dimethyl-4(3H)-quinazolinone 
• 67246-50-8 1-[2-(4-Propionoxy-4-phenylpiperidino)ethyl]-2-phenyl-3-methyl-1,2,3,4-tetrahydro-4-quinazolinone Maleate 

Relevant articles and documents

Direct synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes

A novel catalytic system is reported for the construction of quinazolinones via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides with amides and aldehydes. Subsequent selective hydrosilylation of the quinazolinones using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines with structural diversity. The developed methodology proceeds with a broad substrate scope, excellent functional group tolerance, and utilizes a reusable catalyst and air as a green oxidant.

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

Palladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biologically active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N′-arylbenzimidamides and 2-amino-N′-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.