N-α-Boc-L-Trp-L-His-NHBzl

Base Information

• Chemical Name: N-α-Boc-L-Trp-L-His-NHBzl
• CAS No.: 1184962-81-9
• Molecular Formula: C₂₉H₃₄N₆O₄
• Molecular Weight: 530.627
• Mol file: 1184962-81-9.mol

Synonyms:N-α-Boc-L-Trp-L-His-NHBzl

Chemical Property of N-α-Boc-L-Trp-L-His-NHBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-α-Boc-L-Trp-L-His-NHBzl

There total 8 articles about N-α-Boc-L-Trp-L-His-NHBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(S)-2-tert-Butoxycarbonylamino-3-(3H-imidazol-4-yl)-propionic acid (17791-52-5) + Boc-Trp-OH (13139-14-5) → N-α-Boc-L-Trp-L-His-NHBzl (1184962-81-9)

Guidance literature:

With endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; at 60 ℃; for 0.25h; Microwave irradiation;

DOI:10.1039/c4md00041b

Reference yield: 65.0%

N1-benzyl-(2S)-2-amino-3-(1H-4-imidazolyl)propanamide + Boc-Trp-OH (13139-14-5) → N-α-Boc-L-Trp-L-His-NHBzl (1184962-81-9)

Guidance literature:

Boc-Trp-OH; With endo-N-hydroxy-5-norbornene-2,3-dicarboximide; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at -10 ℃; for 0.0833333h;

N₁-benzyl-(2S)-2-amino-3-(1H-4-imidazolyl)propanamide; In N,N-dimethyl-formamide; at 4 ℃; for 36h;

DOI:10.1021/jm900622d

Reference yield: 60.0%

Boc-Trp-OH (13139-14-5) + N-α-Boc-L-His-NHBzl → N-α-Boc-L-Trp-L-His-NHBzl (1184962-81-9)

Guidance literature:

L-Boc-histidine benzylamide; With hydrogenchloride; In water; at 20 ℃; for 0.25h;

Boc-Trp-OH; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In water; at 60 ℃; under 2068.65 Torr; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.04.120

upstream raw materials:

Boc-Trp-OH

N-α-trifluoroacetyl-L-histidine methyl ester

L-histidine

(S)-2-tert-Butoxycarbonylamino-3-(3H-imidazol-4-yl)-propionic acid

Downstream raw materials:

Boc-His-Trp-His-NHBzl

His-Trp-His-NHBzl

L-Trp-L-His-NHBzl