Technology Process of Boc-His-Trp-His-NHBzl
There total 10 articles about Boc-His-Trp-His-NHBzl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-α-Boc-L-Trp-L-His-NHBzl;
With
hydrogenchloride;
In
water;
at 25 ℃;
for 0.25h;
N-(tert-butoxycarbonyl)-L-histidine;
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
water;
at 60 ℃;
under 2068.65 Torr;
Microwave irradiation;
DOI:10.1016/j.bmcl.2014.04.120
- Guidance literature:
-
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
water;
at 60 ℃;
for 0.5h;
under 2068.65 Torr;
Microwave irradiation;
DOI:10.1016/j.bmcl.2014.04.120
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropyl-carbodiimide; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide / 0.5 h / 60 °C / Microwave irradiation
2.1: hydrogenchloride / water / 0.25 h / 20 °C
2.2: 60 °C / 2068.65 Torr / Microwave irradiation
3.1: hydrogenchloride / water / 0.25 h / 25 °C
3.2: 60 °C / 2068.65 Torr / Microwave irradiation
With
hydrogenchloride; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; diisopropyl-carbodiimide;
In
water;
DOI:10.1016/j.bmcl.2014.04.120
