4,5,6,9,10-Pentamethoxyindeno[1,2,3-ij]isoquinoline

Base Information

• Chemical Name: 4,5,6,9,10-Pentamethoxyindeno[1,2,3-ij]isoquinoline
• CAS No.: 38366-03-9
• Molecular Weight: 0
• Mol file: 38366-03-9.mol

Synonyms:

Chemical Property of 4,5,6,9,10-Pentamethoxyindeno[1,2,3-ij]isoquinoline

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5,6,9,10-Pentamethoxyindeno[1,2,3-ij]isoquinoline

There total 10 articles about 4,5,6,9,10-Pentamethoxyindeno[1,2,3-ij]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3,4-dihydroimeluteine (38366-08-4) → imeluteine (38366-03-9)

Guidance literature:

With palladium on activated charcoal; In decalin; Heating;

DOI:10.1016/S0040-4039(00)92363-3

Reference yield: 50.0%

4,5,6,9,10-Pentamethoxy-indeno[1,2,3-ij]isoquinoline-8-carboxylic acid (91586-04-8) → imeluteine (38366-03-9)

Guidance literature:

With (C₆F₅Cu)2*dioxane; In quinoline; at 220 ℃; for 0.583333h;

DOI:10.1021/jo00195a035

Reference yield:

5-bromo-2,3,4-trimethoxybenzaldehyde (28006-94-2) → imeluteine (38366-03-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Pd(PPh₃)4, 2.) 2M aq. Na₂CO₃ / 1.) DME, RT, 5 min, 2.) DME, EtOH, reflux, 12 h

2: 83 percent / NH₄OAc, glacial acetic acid / 2 h / Heating

3: LiAlH₄ / tetrahydrofuran; diethyl ether / 6 h / Heating

4: 36 percent / LDA / tetrahydrofuran / 10 h / 0 °C

5: 60 percent / decalin / 10percent Pd/C / 3 h / 200 - 220 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; sodium carbonate; acetic acid; decalin; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether;

DOI:10.1139/v94-035

upstream raw materials:

3,4-dihydroimeluteine

4,5,6,9,10-Pentamethoxy-indeno[1,2,3-ij]isoquinoline-8-carboxylic acid

5-bromo-2,3,4-trimethoxybenzaldehyde

2-N,N-diisopropylcarboxamido-3,4-dimethoxyphenyl boronic acid