28006-94-2

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2,3,4-trimethoxy-benzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-Bromo-2,3,4-trimethoxy-benzaldehyde serves as a precursor for the synthesis of various agrochemicals, including pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds.
Used in Natural Product Synthesis:
5-Bromo-2,3,4-trimethoxy-benzaldehyde is also utilized in the synthesis of natural products, such as flavonoids and other bioactive compounds found in plants. Its presence in these molecules can contribute to their biological activities and potential health benefits.
Used in Biological Activity Research:
5-Bromo-2,3,4-trimethoxy-benzaldehyde has been studied for its potential biological activities, including anti-inflammatory and antimicrobial properties. Its unique structure allows for the exploration of its effects on various biological pathways and its potential use in the development of new therapeutic agents.
Used as a Reagent in Organic Synthesis:
In organic synthesis, 5-Bromo-2,3,4-trimethoxy-benzaldehyde can be used as a reagent to introduce the bromo group into organic molecules. This can be particularly useful in the synthesis of halogenated compounds, which often exhibit unique chemical and biological properties.

InChI:InChI=1/C10H11BrO4/c1-13-8-6(5-12)4-7(11)9(14-2)10(8)15-3/h4-5H,1-3H3

Upstream product

• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Downstream Products

• 38366-03-9 imeluteine 
• 250253-65-7 C₂₁H₂₀BrNO₅ 

Relevant academic research and scientific papers

Integrated aromatic metalation - cross coupling methodologies. A concise synthesis of the azafluoranthene alkaloid imeluteine

An efficient synthesis of imeluteine (1e) by a combinational metalation (ortho and remote) - cross coupling approach 2 is described.

Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins

A series of acylpyrogallols were designed, synthesized, and evaluated as small-molecule inhibitors of antiapoptotic Bcl-2 proteins. The most potent compound 9 (TM-179) binds to Bcl-2 with an IC50 of 170 nM and to Mcl-1 with a Ki of 3

SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF

The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

Synthesis and cytotoxic activities of a new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, and some 9-oxygenated benzo[c]phenanthridine derivatives.

[formula: see text] A new benzo[c]phenanthridine alkaloid, 7-hydroxynitidine, was synthesized by a novel synthetic procedure. The cytotoxic activity of this compound against HeLa S3 cells was strong, but not greater than those of its mother compounds, nitidine and NK109. We also synthesized other 9-oxygenated benzo[c]phenanthridine alkaloids, 7-methoxynitidine, 9-demethylnitidine, nitidine, and fagaronine, and tested their cytotoxic activities. These results suggest that the 7-hydroxy group enhances antitumor activity and an 8- or 9-hydroxy group weakens this activity.

Ortho and remote metalation - cross coupling strategies. Total synthesis of the naturally occurring fluorenone dengibsinin and the azafluoranthene alkaloid imeluteine

The total synthesis of the naturally occurring fluorenone, dengibsinin (7a), and the azafluoranthene alkaloid, imeluteine (30e), is described. Using combined ortho metalation - cross coupling sequences that terminate in Friedel-Crafts (18b→6d) and remote