1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

Base Information

Chemical Name:1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil
CAS No.:157224-76-5
Molecular Formula:C₂₈H₂₉F₂N₂O₁₀P
Molecular Weight:622.516
Hs Code.:

Synonyms:1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

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Chemical Property of 1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

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Technology Process of 1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

There total 5 articles about 1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1-O-Acetyl-2,3-di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-D-ribo-hexofuranoside

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 157224-76-5
1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

Guidance literature:: tin(IV) chloride; In acetonitrile; for 2h; Heating;
DOI:10.1016/S0040-4039(00)76871-7

Reference yield:

: 98-88-4
benzoyl chloride

: 157224-76-5
1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / Ambient temperature

2: AcOH, H₂SO₄ / ethyl acetate / 18 h / 0 °C

3: 62 percent / SnCl₄ / acetonitrile / 2 h / Heating

With pyridine; sulfuric acid; acetic acid; tin(IV) chloride; In ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)76871-7

Reference yield:

: 162853-43-2
[2-((2R,3S,4R,5R)-3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-1,1-difluoro-ethyl]-phosphonic acid diethyl ester

: 157224-76-5
1-<2,3-Di-O-benzoyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-β-D-ribo-hexofuranosyl>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 16 h / Ambient temperature

2: AcOH, H₂SO₄ / ethyl acetate / 18 h / 0 °C

3: 62 percent / SnCl₄ / acetonitrile / 2 h / Heating

With pyridine; sulfuric acid; acetic acid; tin(IV) chloride; In ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4039(00)76871-7