C₂₁H₂₀INO₃

Base Information

Chemical Name:C₂₁H₂₀INO₃
CAS No.:1452815-99-4
Molecular Formula:C₂₁H₂₀INO₃
Molecular Weight:461.299
Hs Code.:

C<sub>21</sub>H<sub>20</sub>INO<sub>3</sub>

Synonyms:C₂₁H₂₀INO₃

Suppliers and Price of C₂₁H₂₀INO₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₂₀INO₃

Chemical Property:

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Technology Process of C₂₁H₂₀INO₃

There total 10 articles about C₂₁H₂₀INO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1452815-93-8
C₂₂H₂₂INO₃

: 1452815-99-4
C₂₁H₂₀INO₃

Guidance literature:: With ethanol; sodium hydroxide; In tetrahydrofuran; for 5h; stereoselective reaction; Reflux;
DOI:10.1016/j.tetlet.2013.07.115

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1452815-99-4
C₂₁H₂₀INO₃

Guidance literature:: Multi-step reaction with 8 steps

1: titanium(IV) isopropylate / toluene / 12 h / 100 °C

2: zinc(II) chloride / diethyl ether / -78 - 25 °C

3: potassium hydroxide; water / methanol / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C

5: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C

6: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

7: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 2 h / 0 - 20 °C

8: sodium hydroxide; ethanol / tetrahydrofuran / 5 h / Reflux

With titanium(IV) isopropylate; 15-crown-5; tin(II) chloride dihdyrate; ethanol; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; potassium hydroxide; sodium hydroxide; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; 7: |Sandmeyer Reaction;
DOI:10.1016/j.tetlet.2013.07.115

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 1452815-99-4
C₂₁H₂₀INO₃

Guidance literature:: Multi-step reaction with 9 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 0 - 30 °C

2: toluene-4-sulfonic acid / toluene / 20 h / Reflux

3: zinc(II) chloride / diethyl ether / -78 - 25 °C

4: potassium hydroxide; water / methanol / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C

6: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C

7: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

8: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 2 h / 0 - 20 °C

9: sodium hydroxide; ethanol / tetrahydrofuran / 5 h / Reflux

With aluminum (III) chloride; 15-crown-5; tin(II) chloride dihdyrate; ethanol; water; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; potassium hydroxide; sodium hydroxide; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1: |Friedel-Crafts Acylation / 8: |Sandmeyer Reaction;
DOI:10.1016/j.tetlet.2013.07.115