ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

Base Information

Chemical Name:ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate
CAS No.:1374760-86-7
Molecular Formula:C₂₆H₂₁N₃O₅
Molecular Weight:455.47
Hs Code.:

Synonyms:ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

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Chemical Property of ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

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Technology Process of ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

There total 3 articles about ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 58881-45-1
Indole-2-carbonyl chloride

: 1374760-68-5
ethyl 2-(4-amino-2-benzoylphenylamino)-2-oxoacetate

: 1374760-86-7
ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 110 ℃; for 2h;
DOI:10.1016/j.bmc.2012.03.005

Reference yield:

: 401640-32-2
ethyl 2-(2-benzoyl-4-nitrophenylamino)-2-oxoacetate

: 1374760-86-7
ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / trifluoroethanol / 3 h / 20 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In trifluoroethanol; toluene;
DOI:10.1016/j.bmc.2012.03.005

Reference yield:

: 1775-95-7
2-amino-5-nitrobenzophenone

: 1374760-86-7
ethyl 2-(2-benzoyl-4-(1H-indole-2-carboxamido)phenylamino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 3 h / 110 °C

2: palladium 10% on activated carbon; hydrogen / trifluoroethanol / 3 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / toluene / 2 h / 110 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In trifluoroethanol; toluene;
DOI:10.1016/j.bmc.2012.03.005