(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:1272654-89-3
Molecular Formula:C₁₃H₂₂N₂O₆
Molecular Weight:302.327
Hs Code.:

Synonyms:(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

Suppliers and Price of (2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

There total 1 articles about (2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.9%

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1272654-89-3
(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1272654-89-3
(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

: 1272654-98-4
methyl [(1S)-1-({(2S)-2-[4-(4'-{2-[(3S,7S,9S)-7,9-dimethyl-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-6,10-dioxa-2-azaspiro[4.5]dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / Reflux; Dean stark trap

3.1: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

3.2: pH 3

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.05 h

4.2: 2 h / 20 °C

5.1: ammonium acetate / 1,4-dioxane / 110 °C / Sealed tube

With ammonium acetate; water; Dess-Martin periodane; triethylamine; HATU; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1272654-89-3
(2S,4R)-4-Hydroxy-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid methyl ester

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / Reflux; Dean stark trap

3.1: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

3.2: pH 3

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.05 h

4.2: 2 h / 20 °C

With water; Dess-Martin periodane; triethylamine; HATU; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;