Technology Process of (S)-1-[4'-benzyl-2'-[(3-fluoropropoxy)methyl]piperazin-1'-yl]isoquinoline
There total 7 articles about (S)-1-[4'-benzyl-2'-[(3-fluoropropoxy)methyl]piperazin-1'-yl]isoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at -78 - 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / diethyl ether / 0.25 h / 0 °C
1.2: 14 h / 20 °C
2.1: hydrogenchloride; methanol; water / 3 h / 20 °C
2.2: Saturated solution
3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
3.2: 14.17 h / 0 - 20 °C
4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 0 - 60 °C
4.2: 0 °C
5.1: diethylamino-sulfur trifluoride / dichloromethane / 16 h / -78 - 20 °C
With
hydrogenchloride; methanol; n-butyllithium; diethylamino-sulfur trifluoride; water; sodium hydride; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 0.5 h / 0 °C
1.2: Saturated solution
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Heating / reflux
3.1: n-butyllithium / diethyl ether / 0.25 h / 0 °C
3.2: 14 h / 20 °C
4.1: hydrogenchloride; methanol; water / 3 h / 20 °C
4.2: Saturated solution
5.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
5.2: 14.17 h / 0 - 20 °C
6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 0 - 60 °C
6.2: 0 °C
7.1: diethylamino-sulfur trifluoride / dichloromethane / 16 h / -78 - 20 °C
With
hydrogenchloride; methanol; lithium aluminium tetrahydride; n-butyllithium; diethylamino-sulfur trifluoride; water; sodium hydride; toluene-4-sulfonic acid; 9-bora-bicyclo[3.3.1]nonane;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
