5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Base Information

Chemical Name:5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one
CAS No.:1346674-58-5
Molecular Formula:C₁₅H₁₈BrN₅O
Molecular Weight:364.245
Hs Code.:

Synonyms:5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Suppliers and Price of 5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

There total 1 articles about 5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 571189-16-7
4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1346674-58-5
5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / Inert atmosphere

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol;

Reference yield:

: 1346674-58-5
5-bromo-1-methyl-3-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one

: 2-(3-(5-((5-(4-(cyclopropanecarbonyl)piperazin-1-yl)pyridin-2-yl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: potassium acetate; XPhos; palladium diacetate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; palladium diacetate; sodium carbonate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; water; 2: |Miyaura Borylation Reaction / 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2014.11.006