1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide

Base Information

Chemical Name:1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide
CAS No.:134563-30-7
Molecular Formula:C₁₉H₁₈N₂O₂
Molecular Weight:306.364
Hs Code.:
DSSTox Substance ID:DTXSID701154754
Nikkaji Number:J436.883E

Synonyms:DTXSID701154754;134563-30-7;1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide

Suppliers and Price of 1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:306.136827821
Heavy Atom Count:23
Complexity:518

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)N1C(=C(C2=CC=CC=C2C1=O)C3=CC=CC=C3)C(=O)N

Technology Process of 1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide

There total 4 articles about 1,2-Dihydro-2-(1-methylethyl)-1-oxo-4-phenyl-3-isoquinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 134563-33-0
2-Isopropyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonitrile

: 134563-30-7
2-Isopropyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carboxylic acid amide

Guidance literature:: With potassium hydroxide; In isopropyl alcohol; Heating;
DOI:10.1002/ardp.2503241007

Reference yield:

: 85-52-9
2-Benzoylbenzoic acid

: 134563-30-7
2-Isopropyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 5 h / Heating

2: 39 percent / triethylamine / CH₂Cl₂ / 1) 1 h, r.t. 2) 2 h, 50 deg C

3: 80 percent / NaOCH₃ / methanol / 2 h / Heating

4: 96 percent / KOH / propan-2-ol / Heating

With potassium hydroxide; thionyl chloride; sodium methylate; triethylamine; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1002/ardp.2503241007

Reference yield:

: 18852-53-4
3-chloro-3-phenylphthalide

: 134563-30-7
2-Isopropyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / triethylamine / CH₂Cl₂ / 1) 1 h, r.t. 2) 2 h, 50 deg C

2: 80 percent / NaOCH₃ / methanol / 2 h / Heating

3: 96 percent / KOH / propan-2-ol / Heating

With potassium hydroxide; sodium methylate; triethylamine; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1002/ardp.2503241007