{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

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Chemical Name:{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde
CAS No.:1210969-78-0
Molecular Formula:C₂₈H₄₆O₅Si
Molecular Weight:490.756
Hs Code.:

Synonyms:{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

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Chemical Property of {(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

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Technology Process of {(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

There total 7 articles about {(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1210969-75-7
{(2S,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

: 1210969-78-0
{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

Guidance literature:: With D-Prolin; In methanol; at 0 - 60 ℃; for 4h;
DOI:10.1016/j.tetlet.2009.12.032

Reference yield:

: 1210969-69-9
C₂₂H₃₄O₅

: 1210969-78-0
{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: methanol; camphor-10-sulfonic acid / dichloromethane / 1 h / 0 °C

3: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 5 h / 20 °C

4: D-Prolin / methanol / 4 h / 0 - 60 °C

With methanol; camphor-10-sulfonic acid; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; D-Prolin; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.02.061

Reference yield:

: 1210969-72-4
C₃₄H₆₂O₅Si₂

: 1210969-78-0
{(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; camphor-10-sulfonic acid / dichloromethane / 1 h / 0 °C

2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 5 h / 20 °C

3: D-Prolin / methanol / 4 h / 0 - 60 °C

With methanol; camphor-10-sulfonic acid; sodium hydrogencarbonate; Dess-Martin periodane; D-Prolin; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.02.061