1210969-75-7

Upstream product

• 1210969-73-5 2-{(2S,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}ethanol 
• 1111316-40-5 C₂₃H₃₂O₅ 
• 1204616-82-9 (3aS,5R,7aS)-5-[(1E,6S)-6-(4-methoxybenzyloxy)-1-heptenyl]hexahydrofuro[3,2-b]pyran-2-one 
• 1210969-69-9 C₂₂H₃₄O₅ 
• 1210969-72-4 C₃₄H₆₂O₅Si₂ 

Downstream Products

• 1210969-78-0 {(2R,3S,6R)-3-tert-butyldimethylsilyloxy-6-[(S)-6-(4-methoxybenzyloxy)-1-heptenyl]tetrahydropyran-2-yl}acetaldehyde 

Relevant academic research and scientific papers

Synthesis of aspergillide A via proline-catalyzed trans-to-cis isomerization of a substituted tetrahydropyran

The transformation of a common synthetic intermediate of aspergillides B and C into aspergillide A, a cytotoxin produced by a marine-derived fungus, has been accomplished in an eleven-step sequence involving an efficient proline-catalyzed isomerization of

Synthesis of aspergillide A from a synthetic intermediate of aspergillide B

The first synthesis of aspergillide A, a cytotoxin produced by a marine-derived fungus, has been achieved from a synthetic intermediate of aspergillide B by using a proline-mediated epimerization of a 2,6-trans-substituted tetrahydropyran-2-acetaldehyde intermediate into the corresponding cis-isomer via a retro-oxy-Michael/oxy-Michael sequence as the key transformation.