2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone

Base Information

• Chemical Name: 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone
• CAS No.: 109243-56-3
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 109243-56-3.mol

Synonyms:2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone

Chemical Property of 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone

There total 6 articles about 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-formylbenzyl)-1,4-dimethoxy-3,5-dimethylbenzene (109243-52-9) → 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone (109243-56-3)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; for 1h; Ambient temperature;

DOI:10.1021/jo00226a034

Reference yield:

1,3-dimethyl-2,5-dimethoxybenzene (14538-50-2) → 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone (109243-56-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 67 percent / trifluoroacetic anhydride / 10 h / Heating

2: 80 percent / sodium hydroxide, zinc, cupric sulfate / H₂O / 18 h / Heating

3: 78 percent / LiAlH₄ / tetrahydrofuran / 1.) RT, 2.) reflux, 6h

4: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

5: 100 percent / ceric ammonium nitrate / acetonitrile; H₂O / 1 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; copper(II) sulfate; pyridinium chlorochromate; trifluoroacetic anhydride; zinc; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/jo00226a034

Reference yield:

Monomethyl phthalate (4376-18-5) → 2-(2-formylbenzyl)-3,5-dimethyl-1,4-benzoquinone (109243-56-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 67 percent / trifluoroacetic anhydride / 10 h / Heating

2: 80 percent / sodium hydroxide, zinc, cupric sulfate / H₂O / 18 h / Heating

3: 78 percent / LiAlH₄ / tetrahydrofuran / 1.) RT, 2.) reflux, 6h

4: 96 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

5: 100 percent / ceric ammonium nitrate / acetonitrile; H₂O / 1 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; copper(II) sulfate; pyridinium chlorochromate; trifluoroacetic anhydride; zinc; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/jo00226a034

upstream raw materials:

2-(2-formylbenzyl)-1,4-dimethoxy-3,5-dimethylbenzene

1,3-dimethyl-2,5-dimethoxybenzene

Monomethyl phthalate

2-<2-(hydroxymethyl)benzyl>-1,4-dimethoxy-3.5-dimethylbenzene