1,4-DIMETHOXY-2,6-DIMETHYLBENZENE

Base Information

• Chemical Name: 1,4-DIMETHOXY-2,6-DIMETHYLBENZENE
• CAS No.: 14538-50-2
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Hs Code.: 2909309090
• Mol file: 14538-50-2.mol

Synonyms:2,5-Dimethoxy-1,3-dimethyl-benzol;2.5-Dimethoxy-m-xylol;m-dimethyl-1,4-dimethoxybenzene;2,5-dimethoxy-1,3-dimethyl-benzene;2,6-dimethyl-1,4-hydroquinone dimethyl ether;benzene,2,5-dimethoxy-1,3-dimethyl;1,4-DIMETHOXY-2,6-DIMETHYLBENZENE;1,3-dimethyl-2,5-dimethoxybenzene;

Chemical Property of 1,4-DIMETHOXY-2,6-DIMETHYLBENZENE

Chemical Property:

• PSA: 18.46000
• LogP: 2.32060
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dimethoxy-1,3-dimethylbenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DIMETHOXY-2,6-DIMETHYLBENZENE

There total 15 articles about 1,4-DIMETHOXY-2,6-DIMETHYLBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) + methyl iodide (74-88-4) → 1,3-dimethyl-2,5-dimethoxybenzene (14538-50-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1002/ejoc.200700885

Reference yield: 75.0%

4-methoxy-3,5-dimethylphenol (4962-29-2) + dimethyl sulfate (77-78-1) → 1,3-dimethyl-2,5-dimethoxybenzene (14538-50-2)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Ambient temperature;

Reference yield: 62.0%

1-iodo-2,4-dimethoxybenzene (25245-35-6) + carbonic acid dimethyl ester (616-38-6) → 1,3-dimethyl-2,5-dimethoxybenzene (14538-50-2)

Guidance literature:

1-iodo-2,4-dimethoxybenzene; With tetrabutylammomium bromide; potassium carbonate; palladium dichloride; In N,N-dimethyl acetamide; Schlenk technique; Inert atmosphere;

carbonic acid dimethyl ester; In N,N-dimethyl acetamide; at 105 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.0c13057

upstream raw materials:

1,3-bis-bromomethyl-2,5-dimethoxy-benzene

1,4-dihydroxy-2,6-dimethylbenzene

dimethyl sulfate

4-methoxy-3,5-dimethylphenol

Downstream raw materials:

2,5-dimethoxy-isophthalic acid

3,5-dichloromethyl-2,6-dimethylhydroquinone dimethyl ether

2-<2-(methoxycarbonyl)benzoyl>-1,4-dimethoxy-3,5-dimethylbenzene

3,5-dichloro-2,3',6,6'-tetramethoxy-2',4'-dimethylbenzophenone