2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

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Chemical Name:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide
CAS No.:184710-47-2
Molecular Formula:C₃₄H₃₂F₂N₄O₇
Molecular Weight:646.647
Hs Code.:

Synonyms:2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

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Chemical Property of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

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Technology Process of 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

There total 4 articles about 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 339169-56-1
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-hydroxypropyl]acetamide

: 184710-47-2
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: With dichloro-acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 0 ℃; for 3h;
DOI:10.1021/jm000497n

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 184710-47-2
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Zn / tetrahydrofuran / 0.5 h / 20 °C

2: 100 percent / H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

3: 73 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

4: 53 percent / 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3 h / 0 °C

With N-ethylmorpholine;; hydrogenchloride; dichloro-acetic acid; hydrogen; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; 10percent Pd/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 1: Reformatsky reaction / 4: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000497n

Reference yield:

: 130405-00-4
4-Benzyloxycarbonylamino-2,2-difluoro-3-hydroxy-5-phenyl-pentanoic acid,ethyl ester

: 184710-47-2
2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

2: 73 percent / N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

3: 53 percent / 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; dichloroacetic acid; DMSO / toluene / 3 h / 0 °C

With N-ethylmorpholine;; hydrogenchloride; dichloro-acetic acid; hydrogen; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; N,N-dimethyl-formamide; toluene; 3: modified Pfitzner-Moffatt oxidation;
DOI:10.1021/jm000497n