130405-00-4

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 59830-60-3 N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 

Downstream Products

• 339169-56-1 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-hydroxypropyl]acetamide 
• 184710-47-2 2-[5-benzyloxycarbonylamino-6-oxo-2-(m-tolyl)-1,6-dihydro-1-pyrimidinyl]-N-[1-benzyl-3-(ethoxycarbonyl)-3,3-difluoro-2-oxopropyl]acetamide 
• 184710-49-4 4-[2-(5-amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-acetylamino]-2,2-difluoro-3-oxo-5-phenyl-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

IgE antibody production inhibitors and autoimmune diseases inhibitors

The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an activ

Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase

Potent human chymase inhibitors with high enzymatic selectivity and satisfactory metabolic stability were obtained by replacing the Val-Pro (P3-P2) dipeptide portion of the previously described inhibitor 1 with a nonpeptidic pyrimidi

Inhibitors of β-amyloid protein production

This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it relates to the treatment of Alzheimer's disease.

ANALOG OF PEPTIDASE SUBSTRATES

This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced w

Novel peptidase inhibitors

This invention relates to analogs of peptidase substrates in which the nitrogen atom of the scissile amide bond of a partial retropeptide analog of the substrate has been replaced by a difluoromethylene moiety. These peptidase substrate analogs provide specific enzyme inhibitors for a variety of proteases, the inhibition of which exert valuable pharmacological activities and therefore have useful physiological consequences in a variety of disease states.

Novel peptidase inhibitors

This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates having the formula R1NHCHR2COCF2CHR3(NRbCOXRa)nQ These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and metallo- dependent