ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

Base Information

Chemical Name:ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate
CAS No.:1198181-60-0
Molecular Formula:C₁₇H₁₈F₆O₄
Molecular Weight:400.318
Hs Code.:

Synonyms:ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

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Chemical Property of ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

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Technology Process of ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

There total 5 articles about ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1198181-59-7
ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl}methoxy)acetate

: 1198181-60-0
ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 16h;

Reference yield:

: 73852-19-4
3,5-bis-trifluromethylphenylboronic acid

: 1198181-60-0
ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrahydrofuran / 16 h / Inert atmosphere

2.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 5.5 h / 20 - 80 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

With sodium tetrahydroborate; ethanol; hydrogen; sodium hydride; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198181-60-0
ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrahydrofuran / 16 h / Inert atmosphere

2.1: ethanol; sodium tetrahydroborate / 1 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 5.5 h / 20 - 80 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

With sodium tetrahydroborate; ethanol; hydrogen; sodium hydride; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;