(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

Base Information

Chemical Name:(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid
CAS No.:701269-87-6
Molecular Formula:C₁₅H₁₄F₂N₂O₃
Molecular Weight:308.285
Hs Code.:

Synonyms:(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

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Chemical Property of (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

Chemical Property:

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Technology Process of (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

There total 8 articles about (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid ethyl ester

: 701269-87-6
(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 18h;

Reference yield:

: 701266-27-5
(RS)-[4-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-ethoxy-acetic acid ethyl ester

: 701269-87-6
(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

2: pyridine / 18 h / 0 °C

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 100 °C

4: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 48 h / 80 °C

5: sodium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

With pyridine; sodium hydroxide; tetrabutyl ammonium fluoride; potassium carbonate; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 701266-26-4
(RS)-[4-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester

: 701269-87-6
(RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: silver(l) oxide / toluene / 5.5 h / 20 - 120 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h

3: pyridine / 18 h / 0 °C

4: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 16 h / 100 °C

5: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 48 h / 80 °C

6: sodium hydroxide / tetrahydrofuran; water / 18 h / 20 °C

With pyridine; sodium hydroxide; tetrabutyl ammonium fluoride; potassium carbonate; cesium fluoride; silver(l) oxide; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; toluene;