3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

Base Information

Chemical Name:3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide
CAS No.:1428581-39-8
Molecular Formula:C₃₁H₃₇N₅O₄
Molecular Weight:543.666
Hs Code.:

Synonyms:3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

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Chemical Property of 3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

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Technology Process of 3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

There total 8 articles about 3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428581-05-8
3-(4-(4-((3-(cyclopropylmethoxy)-5-methoxybenzamido)methyl)piperidin-1-yl)pyrimidin-2-yl)benzoic acid

: 75-04-7,85404-22-4
ethylamine

: 1428581-39-8
3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

Guidance literature:: 3-(4-(4-((3-(cyclopropylmethoxy)-5-methoxybenzamido)methyl)piperidin-1-yl)pyrimidin-2-yl)benzoic acid; ethylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

With HATU; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1428582-16-4
N-((1-(2-chloropyrimidin-4-yl)piperidin-4-yl)methyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

: 1428581-39-8
3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

2.1: water; sodium hydroxide / methanol / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

3.2: 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; 1.1: |Suzuki-Miyaura Coupling;

Reference yield:

: 1428582-17-5
methyl 3-(4-(4-((3-(cyclopropylmethoxy)-5-methoxybenzamido)methyl)piperidin-1-yl)pyrimidin-2-yl)benzoate

: 1428581-39-8
3-(cyclopropylmethoxy)-N-((1-(2-(3-(ethylcarbamoyl)phenyl)pyrimidin-4-yl)piperidin-4-yl)methyl)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / methanol / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

2.2: 2 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;