N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine

Base Information

• Chemical Name: N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine
• CAS No.: 885325-30-4
• Molecular Formula: C₂₆H₃₃NO₁₃P₂
• Molecular Weight: 629.494
• Mol file: 885325-30-4.mol

Synonyms:N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine

Chemical Property of N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine

There total 5 articles about N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine hydrochloride + methyl methylphosphonochloridate (1066-52-0) → N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine (885325-30-4)

Guidance literature:

With triethylamine; In dichloromethane; Heating;

DOI:10.1021/ja0600680

Reference yield:

Phosphoric acid diphenyl ester (2R,3S,4R,5R)-3,4,6-trihydroxy-5-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-tetrahydro-pyran-2-ylmethyl ester → N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine (885325-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 15 g / pyridine / 24 h / 20 °C

2: 85 percent / aq. HCl / acetone / Heating

3: 53 percent / Et₃N / CH₂Cl₂ / Heating

With pyridine; hydrogenchloride; triethylamine; In dichloromethane; acetone;

DOI:10.1021/ja0600680

Reference yield:

N-anisylidene 1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine (885325-28-0) → N-methylmethoxyphosphinyl-1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine (885325-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. HCl / acetone / Heating

2: 53 percent / Et₃N / CH₂Cl₂ / Heating

With hydrogenchloride; triethylamine; In dichloromethane; acetone;

DOI:10.1021/ja0600680

upstream raw materials:

methyl methylphosphonochloridate

N-anisylidene 1,3,4-tri-O-acetyl-6-diphenylphosphoroglucosamine

2--2-deoxy-D-glucopyranose

chlorophosphoric acid diphenyl ester