(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid
CAS No.:819858-50-9
Molecular Formula:C₁₃H₁₃BrF₂O₂
Molecular Weight:319.146
Hs Code.:

Synonyms:(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

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Chemical Property of (1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

Chemical Property:

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Technology Process of (1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

There total 8 articles about (1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 819858-49-6
methyl (1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylate

: 819858-50-9
(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 15h;
DOI:10.1021/jm051059p

Reference yield:

: 819858-44-1
(-)-(1R,6R)-6-(2-bromophenyl)cyclohex-3-ene-1-carboxylic acid

: 819858-50-9
(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromotrimethylsilane; dimethyl sulfoxide / CHCl₃ / 1 h / 20 °C

1.2: diisopropylethylamine / CHCl₃ / 24 h / Heating

2.1: methanol / 1.5 h / 20 °C

3.1: aq. H₂SO₄; CrO₃ / acetone / 0.67 h / 20 °C

4.1: Zn; aq. KH₂PO₄ / tetrahydrofuran / 1 h / 20 °C

5.1: diethylaminosulfur trifluoride / CH₂Cl₂; methanol / 2 h / 20 °C

6.1: aq. LiOH / methanol; tetrahydrofuran / 15 h / 20 °C

With chromium(VI) oxide; lithium hydroxide; potassium dihydrogenphosphate; trimethylsilyl bromide; diethylamino-sulfur trifluoride; sulfuric acid; dimethyl sulfoxide; zinc; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetone; 3.1: Jones oxidation;
DOI:10.1021/jm051059p

Reference yield:

: (1R/S,6R/S)-6-(2-bromophenyl)cyclohex-3-ene-1-carboxylic acid

: 819858-50-9
(1R,2R)-2-(2-bromophenyl)-5,5-difluorocyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: (S)-phenylethylamine / tetrahydrofuran

2.1: bromotrimethylsilane; dimethyl sulfoxide / CHCl₃ / 1 h / 20 °C

2.2: diisopropylethylamine / CHCl₃ / 24 h / Heating

3.1: methanol / 1.5 h / 20 °C

4.1: aq. H₂SO₄; CrO₃ / acetone / 0.67 h / 20 °C

5.1: Zn; aq. KH₂PO₄ / tetrahydrofuran / 1 h / 20 °C

6.1: diethylaminosulfur trifluoride / CH₂Cl₂; methanol / 2 h / 20 °C

7.1: aq. LiOH / methanol; tetrahydrofuran / 15 h / 20 °C

With chromium(VI) oxide; lithium hydroxide; potassium dihydrogenphosphate; trimethylsilyl bromide; diethylamino-sulfur trifluoride; sulfuric acid; (S)-1-phenyl-ethylamine; dimethyl sulfoxide; zinc; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetone; 4.1: Jones oxidation;
DOI:10.1021/jm051059p