3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

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Chemical Name:3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide
CAS No.:212698-13-0
Molecular Formula:C₄₀H₄₂Br₄N₄O₁₀
Molecular Weight:1058.41
Hs Code.:

3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

Synonyms:3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

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Chemical Property of 3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

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Technology Process of 3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

There total 7 articles about 3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 212688-12-5
3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-oxo-propionylamino}-butyl)-2-oxo-propionamide

: 212698-13-0
3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; ethanol; at 50 - 60 ℃; for 4h;
DOI:10.1021/jo980860m

Reference yield:

: 209404-16-0
methyl (2-benzyloxy-4-methoxyphenyl)acetate

: 212698-13-0
3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / H₂ / Pd/C / methanol / 7 h / 760 Torr / Ambient temperature

2: 90 percent / pyridinium hydrobromide perbromide / CH₂Cl₂; pyridine / 1 h / Ambient temperature

3: 93 percent / (n-Bu)4NI, 18-crown-6 / acetone / 3 h / Heating

4: 94 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

5: 88 percent / EDCI / CH₂Cl₂ / 4 h / Ambient temperature

6: 1.) O₃ / 1.) CH₂Cl_2. -78 deg C, 5 min, 2.) CH₂Cl₂, room temperature, 1 h

7: 95 percent / NH₂OH*HCl, NaOAc / ethanol; tetrahydrofuran / 4 h / 50 - 60 °C

With sodium hydroxide; 18-crown-6 ether; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium hydrobromide perbromide; tetra-(n-butyl)ammonium iodide; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jo980860m

Reference yield:

: 35353-87-8
methyl (3,5-dibromo-2-hydroxy-4-methoxyphenyl)acetate

: 212698-13-0
3-[3,5-Dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-N-(4-{3-[3,5-dibromo-4-methoxy-2-(4-methoxy-benzyloxy)-phenyl]-2-[(E)-hydroxyimino]-propionylamino}-butyl)-2-[(E)-hydroxyimino]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / (n-Bu)4NI, 18-crown-6 / acetone / 3 h / Heating

2: 94 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

3: 88 percent / EDCI / CH₂Cl₂ / 4 h / Ambient temperature

4: 1.) O₃ / 1.) CH₂Cl_2. -78 deg C, 5 min, 2.) CH₂Cl₂, room temperature, 1 h

5: 95 percent / NH₂OH*HCl, NaOAc / ethanol; tetrahydrofuran / 4 h / 50 - 60 °C

With sodium hydroxide; 18-crown-6 ether; hydroxylamine hydrochloride; sodium acetate; tetra-(n-butyl)ammonium iodide; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetone;
DOI:10.1021/jo980860m