(1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine

Base Information

• Chemical Name: (1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine
• CAS No.: 1256796-16-3
• Molecular Formula: C₂₃H₃₁FN₂O
• Molecular Weight: 370.51

Synonyms:(1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine

Chemical Property of (1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine

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Technology Process of (1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine

There total 1 articles about (1S,2S)-N₁-(2-fluoro-4-isopropoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-fluoro-4-isopropoxyaniline (154080-04-3) + 1-<(1S)-α-phenylethyl>-2,3-tetramethylene aziridine (212071-15-3) → (1S,2S)-N1-(2-fluoro-4-isopropoxyphenyl)-N2-((S)-1-phenylethyl)cyclohexane-1,2-diamine (1256796-16-3) + (1R,2R)-N1-(2-fluoro-4-isopropoxyphenyl)-N2-((S)-1-phenylethyl)cyclohexane-1,2-diamine (1256796-19-6)

Guidance literature:

With tris(pentafluorophenyl)borate; In acetonitrile; at 65 ℃; for 36h; diastereoselective reaction; Inert atmosphere;

DOI:10.3390/molecules15118305

Reference yield:

(1S,2S)-N1-(2-fluoro-4-isopropoxyphenyl)-N2-((S)-1-phenylethyl)cyclohexane-1,2-diamine (1256796-16-3) → C15H23FN2O

Guidance literature:

With 10% palladium on activated carbon; ammonium formate; In methanol; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.3390/molecules15118305

Reference yield:

(1S,2S)-N1-(2-fluoro-4-isopropoxyphenyl)-N2-((S)-1-phenylethyl)cyclohexane-1,2-diamine (1256796-16-3) → 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(2-fluoro-4-isopropoxyphenylamino)cyclohexyl)thiourea (1248337-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; ammonium formate / methanol / 12 h / 60 °C / Inert atmosphere

2: dichloromethane / 3 h / 20 °C / Inert atmosphere

With 10% palladium on activated carbon; ammonium formate; In methanol; dichloromethane;

DOI:10.3390/molecules15118305

upstream raw materials:

2-fluoro-4-isopropoxyaniline

1-<(1S)-α-phenylethyl>-2,3-tetramethylene aziridine

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(2-fluoro-4-isopropoxyphenylamino)cyclohexyl)thiourea

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