212071-15-3

Upstream product

• 666845-36-9 (1'S)-2-[N-(α-phenylethyl)amino]cyclohexanol 
• 666845-36-9 trans-(1'S)2-N-[(α-phenylethyl)amino]cyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 145166-01-4 (1R,2R)-1-N-[(S)-α-phenylethyl]-β-aminocyclohexanol 
• 145166-02-5 (1S,2S)-1-N-[(S)-α-phenylethyl]-β-aminocyclohexanol 

Downstream Products

• 678991-70-3 (1S,2S,1'S,1S)-trans-N,N'-bis[(S)-α-phenylethyl]-1,2-diaminocyclohexane 
• 678991-71-4 (1R,2R,1'S,1S)-trans-N,N'-bis-[(S)-α-phenylethyl]-1,2-diaminocyclohexane 
• 909725-88-8 (1S,2S)-2-azido-N-[(S)-α-phenylethyl]cyclohexanamine 
• 909725-80-0 (1S,2S)-N-[(S)-α-phenylethyl]-cyclohexane-1,2-diamine 
• 1187923-40-5 (1S,2S,1'S)-[(1'-phenylethyl)-(2-phenylselenyl-cyclohexyl)amine] 
• 1187923-41-6 (1R,2R,1'S)-[(1'-phenylethyl)-(2-phenylselenyl-cyclohexyl)amine] 
• 1372857-84-5 (1S,2S)-2-fluoro-N-((S)-1-phenylethyl)cyclohexanamine 
• 1372857-85-6 C₁₄H₂₀FN 
• 1372857-86-7 tert-butyl ((1S,2S)-2-fluorocyclohexyl)carbamate 
• 1256796-15-2 (1S,2S)-N₁-(2,4-dimethoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine 
• 1256796-18-5 (1R,2R)-N₁-(2,4-dimethoxyphenyl)-N₂-((S)-1-phenylethyl)cyclohexane-1,2-diamine 
• 1248337-31-6 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(2-fluoro-4-isopropoxyphenylamino)cyclohexyl)thiourea 
• 1248337-30-5 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(2,4-dimethoxyphenylamino)cyclohexyl)thiourea 
• 1248337-28-1 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2S)-2-(2-fluoro-4-methoxyphenylamino)cyclohexyl)thiourea 

Relevant academic research and scientific papers

Synthesis of β-fluoroamines by Lewis base catalyzed hydrofluorination of aziridines

Lewis base catalysis promotes the in situ generation of amine-HF reagents from benzoyl fluoride and a non-nucleophilic alcohol. The hydrofluorination of aziridines to provide β-fluoroamines using this latent HF source is described. This protocol displays a broad scope with respect to aziridine substitution and N-protecting groups. Examples of regio- and diastereoselective ring opening to access medicinally relevant β-fluoroamine building blocks are presented.

Highly enantioselective organocatalytic syn- And anti-aldol reactions in aqueous medium

We have synthesized chiral diamines that efficiently catalyze the syn- and anti-aldol reactions in aqueous medium with high diastereo- and enantioselectivities. The product, thus obtained, was further reduced selectively to give syn-configured 1,2,3-triol

Use of diamines containing the α-phenylethyl group as chiral ligands in the asymmetric hydrosilylation of prochiral ketones

Chiral diamines 1-7 were used in the enantioselective hydrosilylation of prochiral aromatic and aliphatic ketones. Some of these ligands combine chiral backbones and chiral N,N′-α-phenylethyl substituents that give rise to synergistic effects between these two groups and lead to catalysts that exhibit high enantioselectivity.

Preparation of trans-1,2-diaminocyclohexane derivatives by lithium perchlorate catalyzed ring opening of aziridines

N,N′-Dialkylated trans-1,2-diaminocyclohexane derivatives were synthesized with good overall yield via reaction of the corresponding N-alkylated cyclohexene aziridine with amines, in the presence of lithium perchlorate as catalyst.

O.N-Bis(diphenylphosphino) Derivatives of Chiral trans- and cis-2-Aminocyclohexanols: Synthesis and Enantioselective Behaviour as Ligands in Rh-based Homogeneous Hydrogenation Catalysts

trans- and cis-2-Methylamino cyclohexanols (MAC) were prepared in enantiomerically pure forms and transformed into O.N-bis(diphenylphosphino) derivatives ("PONP").An analogous trans-1R;2R-aminocyclohexanol PONP could only be isolated in an impure form, whereas the attempted synthesis of PONP's of diastereomeric trans-2-(N-α-phenylethylamino)-cyclohexanols failed.Cationic Rh(I)-chelates of the new PONP's catalyzed the enantioselective hydrogenation of dehydro-α-acylamino acids with /= 97percent ee.A comparison of the enantiodiscriminating properties of the MAC-PONP's with structurally related chiral ligands leads to surprising conclusions.