tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate
CAS No.:1338473-95-2
Molecular Formula:C₂₂H₁₉BrCl₃F₃N₂O₃
Molecular Weight:602.663
Hs Code.:

Synonyms:tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

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Chemical Property of tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

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Technology Process of tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

There total 10 articles about tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 864736-87-8
1,2,3-trichloro-5-(1,1,1-trifluoroprop-2-en-2-yl)benzene

: 1338473-94-1
tert-butyl 2-bromo-5-(chloro(hydroxyimino)methyl)benzyl-carbamate

: 1338473-95-2
tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

Guidance literature:: With sodium hydrogencarbonate; at 20 ℃; for 12h;

Reference yield:

: 862248-93-9
(3,4,5-trichlorophenyl)boronic acid

: 1338473-95-2
tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / Reflux

2: sodium hydrogencarbonate / 12 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water;

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1338473-95-2
tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux

2: sodium azide / dimethyl sulfoxide / 4 h / 20 °C

3: triphenylphosphine; water / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C

5: sodium tetrahydroborate; methanol / tetrahydrofuran / 3.33 h / 40 - 45 °C / Inert atmosphere

6: Dess-Martin periodane / dichloromethane / 2.33 h / 0 - 20 °C

7: hydroxylamine hydrochloride; sodium acetate / ethanol / 4 h / 20 °C

8: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C

9: sodium hydrogencarbonate / 12 h / 20 °C

With methanol; sodium tetrahydroborate; N-chloro-succinimide; N-Bromosuccinimide; sodium azide; hydroxylamine hydrochloride; water; sodium acetate; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;