Technology Process of (2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)methanamine
There total 12 articles about (2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)methanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 2-bromo-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzylcarbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / Reflux
2: sodium azide / dimethyl sulfoxide / 4 h / 20 °C
3: triphenylphosphine; water / tetrahydrofuran / 20 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C
5: sodium tetrahydroborate; methanol / tetrahydrofuran / 3.33 h / 40 - 45 °C / Inert atmosphere
6: Dess-Martin periodane / dichloromethane / 2.33 h / 0 - 20 °C
7: hydroxylamine hydrochloride; sodium acetate / ethanol / 4 h / 20 °C
8: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C
9: sodium hydrogencarbonate / 12 h / 20 °C
10: trifluoroacetic acid / dichloromethane / 20 °C
With
methanol; sodium tetrahydroborate; N-chloro-succinimide; N-Bromosuccinimide; sodium azide; hydroxylamine hydrochloride; water; sodium acetate; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / Reflux
2: sodium hydrogencarbonate / 12 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 20 °C
With
sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane; water;
