Technology Process of (2R,3R)-2-[(tert-butoxycarbonyl)amino]-3-phenylbutanol
There total 21 articles about (2R,3R)-2-[(tert-butoxycarbonyl)amino]-3-phenylbutanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at -20 ℃;
for 5h;
DOI:10.1021/jo971178f
- Guidance literature:
-
Multi-step reaction with 8 steps
2: KOH / ethanol
3: diethyl ether
4: 80 percent / KHCO3 / dimethylformamide / 5 h / 20 °C
5: 91 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / 0 - 20 °C
6: sodium azide / dimethylformamide / 12 h / 80 °C
7: 0.07 g / H2 / Pd/C / ethyl acetate / 760 Torr
8: 81 percent / DIBALH / CH2Cl2; hexane / 5 h / -20 °C
With
dmap; potassium hydroxide; sodium azide; hydrogen; diisobutylaluminium hydride; potassium hydrogencarbonate; triethylamine;
palladium on activated charcoal;
In
diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
1: Jacobsen's epoxidation / 2: Hydrolysis / 3: Ring cleavage / 4: Esterification / 5: mesylation / 6: Substitution / 7: Catalytic hydrogenation / 8: Reduction;
DOI:10.1021/jo971178f
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium bicarbonate; sodium periodate / ruthenium trichloride trihydrate / CCl4; acetonitrile; H2O / 48 h
2.1: CuCN / diethyl ether; hexane / 0 °C
2.2: diethyl ether; hexane / 4 h / 0 °C
3.1: 0.18 g / KHCO3 / dimethylformamide / 12 h / 20 °C
4.1: 93 percent / PPh3; diethyl azodicarboxylate / benzene / 12 h / 20 °C
5.1: 0.29 g / aq. LiOH / tetrahydrofuran / 0.58 h / 70 °C
6.1: 80 percent / KHCO3 / dimethylformamide / 5 h / 20 °C
7.1: 91 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / 0 - 20 °C
8.1: sodium azide / dimethylformamide / 12 h / 80 °C
9.1: 0.07 g / H2 / Pd/C / ethyl acetate / 760 Torr
10.1: 81 percent / DIBALH / CH2Cl2; hexane / 5 h / -20 °C
With
dmap; lithium hydroxide; sodium periodate; sodium azide; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
ruthenium trichloride; palladium on activated charcoal;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;
1.1: Oxidation / 2.1: transmetallation / 2.2: Ring cleavage / 3.1: Esterification / 4.1: Mitsunobu reaction / 5.1: Hydrolysis / 6.1: Esterification / 7.1: mesylation / 8.1: Substitution / 9.1: Catalytic hydrogenation / 10.1: Reduction;
DOI:10.1021/jo971178f
![methyl (2R,3R)-2-[(tert-butoxycarbonyl)amino]-3-phenylbutanoate](/Databaselist/images/loading.webp)
